ArticlePrion
The effects of amino acid composition on yeast prion formation and prion domain interactions.
Article in Prion. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies.Nature communications · 2021Article
- The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions.Molecular biology of the cell · 2020Article
- Short disordered protein segment regulates cross-species transmission of a yeast prion.Nature chemical biology · 2020Article
- Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes.BMC genomics · 2020Article
- Physiological, Pathological, and Targetable Membraneless Organelles in Neurons.Trends in neurosciences · 2019Review
- Prion Replication in the Mammalian Cytosol: Functional Regions within a Prion Domain Driving Induction, Propagation, and Inheritance.Molecular and cellular biology · 2018Article
- Sequence features governing aggregation or degradation of prion-like proteins.PLoS genetics · 2018Article
- Chaperone functional specificity promotes yeast prion diversity.PLoS pathogens · 2018Article
- Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.The EMBO journal · 2017Article
- Article
- Effects of Mutations on the Aggregation Propensity of the Human Prion-Like Protein hnRNPA2B1.Molecular and cellular biology · 2017Article
- Amyloids or prions? That is the question.Prion · 2015Review
- What makes a protein sequence a prion?PLoS computational biology · 2015Article
- Effect of domestication on the spread of the [PIN+] prion in Saccharomyces cerevisiae.Genetics · 2014Article
- Increasing prion propensity by hydrophobic insertion.PloS one · 2014Article
- Ion-specific effects on prion nucleation and strain formation.The Journal of biological chemistry · 2013Article
- Heterologous gln/asn-rich proteins impede the propagation of yeast prions by altering chaperone availability.PLoS genetics · 2013Article
- De novo design of synthetic prion domains.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A small, glutamine-free domain propagates the [SWI(+)] prion in budding yeast.Molecular and cellular biology · 2011Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yeast prions provide a powerful model system for examining prion formation and propagation in vivo. Yeast prion formation is driven primarily by amino acid composition, not by primary amino acid sequence. However, although yeast prion domains are consistently glutamine/asparagine-rich, they otherwise vary significantly in their compositions. Therefore, elucidating the exact compositional requirements for yeast prion formation has proven challenging. We have developed an in vivo method that allows for estimation of the prion propensity of each amino acid within the context of a yeast prion domain.(1) Using these values, we are able to predict the prion-propensity of various glutamine/asparagine-rich yeast domains. These results provide insight into the basis for yeast prion formation, and may aid in the discovery of additional novel prion domains. Additionally, we examined whether amino acid composition could drive interactions between heterologous glutamine/asparagine-rich proteins.(2) Although inefficient interactions between yeast prion domains have previously been observed, we found that one prion protein, Ure2, is able to interact with compositionally similar domains with unprecedented efficiency. This observation, combined with the growing number of yeast prions, suggests that a broad network of interactions between heterologous glutamine/asparagine-rich proteins may affect yeast prion formation.
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