ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Analysis of complex biomarkers for human immune-mediated disorders based on cytokine responsiveness of peripheral blood cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed.
- Prune Consumption Attenuates Proinflammatory Cytokine Secretion and Alters Monocyte Activation in Postmenopausal Women: Secondary Outcome Analysis of a 12-Mo Randomized Controlled Trial: The Prune Study.The Journal of nutrition · 2024Trial
- Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis.Annals of the rheumatic diseases · 2013Trial
- Inflammatory state moderates response to cannabis on negative affect and sleep quality in individuals with anxiety.Frontiers in behavioral neuroscience · 2025Article
- Predicting multiple sclerosis prognosis using AI and machine learning: integrating clinical, immunological, and radiological variables.Frontiers in neurology · 2025Article
- The Contribution of the Skin Microbiome to Psoriasis Pathogenesis and Its Implications for Therapeutic Strategies.Medicina (Kaunas, Lithuania) · 2024Review
- Associations between PBMC whole genome transcriptome, muscle strength, muscle mass, and physical performance in healthy home-dwelling older women.GeroScience · 2023Article
- Plant-produced recombinant cytokines IL-37b and IL-38 modulate inflammatory response from stimulated human PBMCs.Scientific reports · 2022Article
- Single-cell transcriptomic and chromatin accessibility analyses of dairy cattle peripheral blood mononuclear cells and their responses to lipopolysaccharide.BMC genomics · 2022Article
- Benefits of Chimeric Antigen Receptor T-Cell Therapy for B-Cell Lymphoma.Frontiers in genetics · 2021Article
- Article
- Longitudinal relationships between rheumatoid factor and cytokine expression by immunostimulated peripheral blood lymphocytes from patients with rheumatoid arthritis: New insights into B-cell activation.Clinical immunology (Orlando, Fla.) · 2020Article
- CytokineExplore: An Online Tool for Statistical Analysis of Cytokine Concentration Datasets.Journal of inflammation research · 2020Article
- Dynamic metrics-based biomarkers to predict responders to anti-PD-1 immunotherapy.British journal of cancer · 2019Article
- Multivariate analysis of cytokine profiles in pregnancy complications.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Patterns of circulatory and peripheral blood mononuclear cytokines in rheumatoid arthritis.Rheumatology international · 2017Article
- Association of self-reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women.Journal of inflammation research · 2017Article
- Immune response profiling in early rheumatoid arthritis: discovery of a novel interaction of treatment response with viral immunity.Arthritis research & therapy · 2013Observational
- Article
- Hepatoprotective effects of baicalein against CCl₄-induced acute liver injury in mice.World journal of gastroenterology · 2012Article
- A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis.Arthritis research & therapy · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The advent of improved biomarkers promises to enhance the clinical care for patients with rheumatoid arthritis (RA) and other immune-mediated disorders. We have developed an innovative approach to broadly assess the cytokine responsiveness of human PBMCs using a multistimulant panel and multiplexed immunoassays. The objective of this study was to demonstrate this concept by determining whether cytokine profiles could discriminate RA patients according to disease stage (early versus late) or severity. A 10-cytokine profile, consisting of IL-12, CCL4, TNF-alpha, IL-4, and IL-10 release in response to stimulation with anti-CD3/anti-CD28, CXCL8 and IL-6 in response to CMV and EBV lysate, and IL-17A, GM-CSF, and CCL2 in response to human heat shock protein 60, easily discriminated the early RA group from controls. These data were used to create an immune response score, which performed well in distinguishing the early RA patients from controls and also correlated with several markers of disease severity among the patients with late RA. In contrast, the same 10-cytokine profile assessed in serum was far less effective in discriminating the groups. Thus, our approach lays the foundation for the development of immunologic "signatures" that could be useful in predicting disease course and monitoring the outcomes of therapy among patients with immune-mediated diseases.
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Registered trials
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