ArticleBrain and cognition2010
Functional imaging of working memory and peripheral endothelial function in middle-aged adults.
Article in Brain and cognition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Exercise as therapy for neurodevelopmental and cognitive dysfunction in people with a Fontan circulation: A narrative review.Frontiers in pediatrics · 2023Review
- Cerebrovascular Function, Vascular Risk, and Lifestyle Patterns in Resistant Hypertension.Journal of Alzheimer's disease : JAD · 2022Article
- Cognition, Brain Structure, and Brain Function in Individuals with Obesity and Related Disorders.Current obesity reports · 2020Review
- Exercise Improves Vascular Function, but does this Translate to the Brain?Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Circulating Cellular Adhesion Molecules and Cognitive Function: The Coronary Artery Risk Development in Young Adults Study.Frontiers in cardiovascular medicine · 2017Article
- Vascular Function in Alzheimer's Disease and Vascular Dementia.American journal of Alzheimer's disease and other dementias · 2016Article
- Cerebral/Peripheral Vascular Reactivity and Neurocognition in Middle-Age Athletes.Medicine and science in sports and exercise · 2015Article
- Vitamin D deficiency and its relationship with endothelial dysfunction in patients with early Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Inflammation as a mediator of the relationship between cortical thickness and metabolic syndrome.Brain imaging and behavior · 2015Article
- Relations of arterial stiffness and endothelial function to brain aging in the community.Neurology · 2013Article
- Subclinical vascular disease and cerebral glutamate elevation in metabolic syndrome.Metabolic brain disease · 2012Article
- Functional MR imaging evidence of altered functional activation in metabolic syndrome.AJNR. American journal of neuroradiology · 2011Article
- Current serum lipoprotein levels and FMRI response to working memory in midlife.Dementia and geriatric cognitive disorders · 2011Article
- Surgical and Nonsurgical Interventions for Obesity in Service of Preserving Cognitive Function.Psychosomatic medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (beta=0.338, p=0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5,36)=2.66, p=0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.