Evidence map›Paper›PMID 20493262›Full record

ReviewNeurobiology of disease2010

Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes.

Priya Mathur, Su Guo

Abstract readReview
In one paragraph

Review in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
  2. Zebrafish (Biology · 2025
    Article
  3. Article
  4. Article
  5. Dynamic Regulation ofInternational journal of molecular sciences · 2023
    Article
  6. Review
  7. Towards Modeling Anhedonia and Its Treatment in Zebrafish.The international journal of neuropsychopharmacology · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Frontiers in neuroscience · 2022
    Article
  12. Coumarins fromInternational journal of molecular sciences · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. CRISPR/Cas9-inducedMolecular autism · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Priya MathurDepartment of Bioengineering and Therapeutic Sciences, Programs in Human Genetics and Biological Sciences, University of California San Francisco, CA 94143-2811, USA.
Su Guo

Funding

Development of Dopaminergic Neurons in ZebrafishR01NS042626 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUO, SU · 2003 to 2012
$3.4M
An in vivo cellular model to study the biological effects of alcoholR01AA016021 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUO, SU · 2006 to 2010
$1.8M
Chemical Genetics to Elucidate the Development of Dopaminergic NeuronsR01DA023904 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUO, SU · 2008 to 2012
$1.7M
NIAAA NIH HHS R01 AA016021NIDA NIH HHS R01 DA023904NINDS NIH HHS R01 NS042626
6 · The paper itself

Abstract

Despite massive research efforts the exact pathogenesis and pathophysiology of addiction and neuropsychiatric disorders such as anxiety, schizophrenia and autism remain largely unknown. Animal models can serve as tools to understand the etiology and pathogenesis of these disorders. In recent years researchers are turning to zebrafish as it allows easy access to all developmental stages and imaging of pathological processes as well as automated behavioral quantification coupled with large scale screening and mutagenesis strategies. This review summarizes studies conducted over the last few years which demonstrate the relevance of the zebrafish model to human diseases including addiction and neuropsychiatric disorders.

Indexed as

Models, GeneticAnimalsBehavior, AnimalDisease Models, AnimalGenetic Predisposition to DiseaseHumansSubstance-Related DisordersZebrafish

Identifiers

PMID20493262
PMCPMC3021971

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.