ArticleNeurobiology of disease2010
Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle.
Article in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of Long-Term Carprofen and Omeprazole Administration in C57BL/6J Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Interactions between daily sleep-wake rhythms, γ-secretase, and amyloid-β peptide pathology point to complex underlying relationships.Biochimica et biophysica acta. Molecular basis of disease · 2025Article
- Review
- Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan.Neurobiology of aging · 2017Article
- A Novel Small Molecule Modulator of Amyloid Pathology.Journal of Alzheimer's disease : JAD · 2016Article
- Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease.Neurobiology of aging · 2015Article
- Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer's disease.Neuroscience · 2015Article
- Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia.Acta neuropathologica communications · 2014Article
- Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2014Article
- Nucleic acid oxidation: an early feature of Alzheimer's disease.Journal of neurochemistry · 2014Article
- Primary over-expression of AβPP in muscle does not lead to the development of inclusion body myositis in a new lineage of the MCK-AβPP transgenic mouse.International journal of experimental pathology · 2013Article
- 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain.Endocrinology · 2012Article
- Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease.Annals of neurology · 2012Article
- Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.Biochimica et biophysica acta · 2012Article
- Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression.Journal of Alzheimer's disease : JAD · 2012Article
- Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2012Article
- BACE2 expression increases in human neurodegenerative disease.The American journal of pathology · 2012Article
- Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation.Neurobiology of disease · 2011Article
- RNA oxidation adducts 8-OHG and 8-OHA change with Aβ42 levels in late-stage Alzheimer's disease.PloS one · 2011Article
- APP(DeltaNL695) expression in murine tissue downregulates CNBP expression.Neuroscience letters · 2010Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Sporadic inclusion body myositis (sIBM) is a common age-related inflammatory myopathy characterized by the presence of intracellular inclusions that contain the amyloid-beta (Abeta) peptide, a derivative of the amyloid precursor protein (APP). Abeta is believed to cause Alzheimer's disease (AD), suggesting that a link may exist between the two diseases. If AD and sIBM are linked, then treatments that lower Abeta in brain may prove useful for sIBM. To test this hypothesis, transgenic mice that overexpress APP in skeletal muscle were treated for 6 months with a variety of nonsteroidal anti-inflammatory drugs (NSAIDs; naproxen, ibuprofen, carprofen or R-flurbiprofen), a subset of which reduce Abeta in brain and cultured cells. Only ibuprofen lowered Abeta in muscle, and this was not accompanied by corresponding improvements in phenotype. These results indicate that the effects of NSAIDs in the brain may be different from other tissues and that Abeta alone cannot account for skeletal muscle dysfunction in these mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.