ArticleFree radical biology & medicine2010
Pluronic-modified superoxide dismutase 1 attenuates angiotensin II-induced increase in intracellular superoxide in neurons.
Article in Free radical biology & medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- The Pathophysiology of Alcohol-Associated Liver Disease: Focusing on Superoxide Dismutase 1 as a Therapeutic Target.Biology · 2025Review
- The Role of Lysyl Oxidase in the Pathological Stage of Atherosclerosis: Structural Stabilizer or Disease Driver?Current atherosclerosis reports · 2025Review
- Enzyme-Based Anti-Inflammatory Therapeutics for Inflammatory Diseases.Pharmaceutics · 2025Review
- Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue Engineering, Antimicrobial, and Agro-Food Applications.Nanomaterials (Basel, Switzerland) · 2022Review
- Nanoformulated SOD1 ameliorates the combined NASH and alcohol-associated liver disease partly via regulating CYP2E1 expression in adipose tissue and liver.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Temperature-Dependent Rheological and Viscoelastic Investigation of a Poly(2-methyl-2-oxazoline)-b-poly(2-Journal of functional biomaterials · 2019Article
- Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Targeted endothelial nanomedicine for common acute pathological conditions.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation.Oxidative medicine and cellular longevity · 2015Article
- Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity.Journal of controlled release : official journal of the Controlled Release Society · 2014Article
- Agile delivery of protein therapeutics to CNS.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
- HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes--the ultimate approach for intra- and extracellular superoxide detection.Biochimica et biophysica acta · 2014Review
- Nanocarriers for vascular delivery of anti-inflammatory agents.Annual review of pharmacology and toxicology · 2014Review
- Brain delivery of proteins via their fatty acid and block copolymer modifications.Journal of drug targeting · 2013Review
- Antioxidant-based therapies for angiotensin II-associated cardiovascular diseases.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Review
- A simple way to enhance Doxil® therapy: drug release from liposomes at the tumor site by amphiphilic block copolymer.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- Conjugates of superoxide dismutase 1 with amphiphilic poly(2-oxazoline) block copolymers for enhanced brain delivery: synthesis, characterization and evaluation in vitro and in vivo.Molecular pharmaceutics · 2013Article
- Poly(2-oxazoline)s as polymer therapeutics.Macromolecular rapid communications · 2012Review
- Well-defined cross-linked antioxidant nanozymes for treatment of ischemic brain injury.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- Targeted interception of signaling reactive oxygen species in the vascular endothelium.Therapeutic delivery · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 4 countries.
Funding
Abstract
Overexpressing superoxide dismutase 1 (SOD1; also called Cu/ZnSOD), an intracellular superoxide (O(2)(*-))-scavenging enzyme, in central neurons inhibits angiotensin II (AngII) intraneuronal signaling and normalizes cardiovascular dysfunction in diseases associated with enhanced AngII signaling in the brain, including hypertension and heart failure. However, the blood-brain barrier and neuronal cell membranes impose a tremendous impediment for the delivery of SOD1 to central neurons, which hinders the potential therapeutic impact of SOD1 treatment on these diseases. To address this, we developed conjugates of SOD1 with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer (Pluronic) (SOD1-P85 and SOD1-L81), which retained significant SOD1 enzymatic activity. The modified SOD1 effectively scavenged xanthine oxidase/hypoxanthine-derived O(2)(*-), as determined by HPLC and the measurement of 2-hydroxyethidium. Using catecholaminergic neurons, we observed an increase in neuronal uptake of SOD1-Pluronic after 1, 6, or 24h, compared to neurons treated with pure SOD1 or PEG-SOD1. Importantly, without inducing neuronal toxicity, SOD1-Pluronic conjugates significantly inhibited AngII-induced increases in intraneuronal O(2)(*-) levels. These data indicate that SOD1-Pluronic conjugates penetrate neuronal cell membranes, which results in elevated intracellular levels of functional SOD1. Pluronic conjugation may be a new delivery system for SOD1 into central neurons and therapeutically beneficial for AngII-related cardiovascular diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.