ArticleVirology journal2010
The novel HSV-1 US5-1 RNA is transcribed off a domain encoding US5, US4, US3, US2 and alpha22.
Article in Virology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Integrative functional genomics decodes herpes simplex virus 1.Nature communications · 2020Article
- Molecular characterization and antiapoptotic function analysis of the duck plague virus Us5 gene.Scientific reports · 2019Article
- Article
- Transcriptional interference networks coordinate the expression of functionally related genes clustered in the same genomic loci.Frontiers in genetics · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe genome of herpes simplex virus 1 encodes at least 84 transcripts from which proteins are translated and several additional RNAs whose status as mRNAs is unknown. These RNAs include latency-associated transcript, OriS1 and OriS2 RNAs and in case of alpha4 null mutant additional transcript that spans the junction between L and S component of the HSV-1 genome. Current data do not suggest that a peptide is translated from these RNAs.
resultsWe describe here a novel RNA designated US5-1 that spans 4.5 kb of the unique-short (US) region. The RNA initiates in US5 and terminates in the alpha22 open reading frame. It is expressed antisense to US5, US4, US3 and ICP22 mRNAs. This transcript is expressed with gamma2 kinetics and has a half-life of 80 minutes.
conclusionThese results identify a novel transcript encoded within HSV-1 genome. Since no major hypothetical open-reading frames are present in this transcript it is feasible that this RNA exerts its function as a non-coding RNA.
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