ArticleSports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT2010
Functional tissue engineering of ligament healing.
Article in Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Nano-layered tendon patch to orchestrate timely interactions between tendon stem/progenitor cells and macrophages.Biomaterials · 2027Article
- Review
- Loss of periostin function impairs ligament fibroblast activity and facilitates ROS-mediated cellular senescence.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Graft Selection Between Tendon Autograft and Allograft in Anterior Cruciate Ligament Reconstruction Based on the Histological Perspective: A Meta-Analysis.Revista brasileira de ortopedia · 2023Article
- Posterior cruciate ligament repair seems safe with low failure rates but more high level evidence is needed: a systematic review.Journal of experimental orthopaedics · 2023Review
- Influence of type I collagen polymorphisms and risk of anterior cruciate ligament rupture in athletes: a case-control study.BMC musculoskeletal disorders · 2022Article
- The novel epiligament theory: differences in healing failure between the medial collateral and anterior cruciate ligaments.Journal of experimental orthopaedics · 2022Review
- Oxo-M and 4-PPBP DeliveryFrontiers in bioengineering and biotechnology · 2022Article
- The Role of Mesenchymal Stem Cells (MSCs) in Veterinary Medicine and Their Use in Musculoskeletal Disorders.Biomolecules · 2021Review
- Functional and Radiographic Outcomes of Intraoperatively Decreasing the Coracoclavicular Distance to 50% of the Unaffected Side in Stabilization of Acute Acromioclavicular Joint Injury: A Retrospective Evaluation.Orthopaedic journal of sports medicine · 2021Article
- Bioinspired Scaffold Designs for Regenerating Musculoskeletal Tissue Interfaces.Regenerative engineering and translational medicine · 2020Article
- Does Manual Drilling Improve the Healing of Bone-Hamstring Tendon Grafts in Anterior Cruciate Ligament Reconstruction? A Histological and Biomechanical Study in a Rabbit Model.Orthopaedic journal of sports medicine · 2020Article
- Review
- A Combination of Oxo-M and 4-PPBP as a potential regenerative therapeutics for tendon injury.Theranostics · 2019Article
- Biomimetic substrate control of cellular mechanotransduction.Biomaterials research · 2016Review
- Positive effects of an extracellular matrix hydrogel on rat anterior cruciate ligament fibroblast proliferation and collagen mRNA expression.Journal of orthopaedic translation · 2015Article
- Harnessing endogenous stem/progenitor cells for tendon regeneration.The Journal of clinical investigation · 2015Article
- Overrepresentation of the COL3A1 AA genotype in Polish skiers with anterior cruciate ligament injury.Biology of sport · 2015Article
- Updates in biological therapies for knee injuries: anterior cruciate ligament.Current reviews in musculoskeletal medicine · 2014Article
- Allografts in soft tissue reconstructive procedures: important considerations.Sports health · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ligaments and tendons are dense connective tissues that are important in transmitting forces and facilitate joint articulation in the musculoskeletal system. Their injury frequency is high especially for those that are functional important, like the anterior cruciate ligament (ACL) and medial collateral ligament (MCL) of the knee as well as the glenohumeral ligaments and the rotator cuff tendons of the shoulder. Because the healing responses are different in these ligaments and tendons after injury, the consequences and treatments are tissue- and site-specific. In this review, we will elaborate on the injuries of the knee ligaments as well as using functional tissue engineering (FTE) approaches to improve their healing. Specifically, the ACL of knee has limited capability to heal, and results of non-surgical management of its midsubstance rupture have been poor. Consequently, surgical reconstruction of the ACL is regularly performed to gain knee stability. However, the long-term results are not satisfactory besides the numerous complications accompanied with the surgeries. With the rapid development of FTE, there is a renewed interest in revisiting ACL healing. Approaches such as using growth factors, stem cells and scaffolds have been widely investigated. In this article, the biology of normal and healing ligaments is first reviewed, followed by a discussion on the issues related to the treatment of ACL injuries. Afterwards, current promising FTE methods are presented for the treatment of ligament injuries, including the use of growth factors, gene delivery, and cell therapy with a particular emphasis on the use of ECM bioscaffolds. The challenging areas are listed in the future direction that suggests where collection of energy could be placed in order to restore the injured ligaments and tendons structurally and functionally.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.