ArticleFEMS yeast research2010
Antimicrobial peptide MUC7 12-mer activates the calcium/calcineurin pathway in Candida albicans.
Article in FEMS yeast research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- WHO Critical Priority Fungi: A Comprehensive Review of Antifungal Resistance, Emerging Therapeutic Strategies, and the Potential of Antifungal Peptides.International journal of molecular sciences · 2026Review
- Salivary Proteome Role in Infection and Immunity.Advances in experimental medicine and biology · 2026Review
- Therapeutic Effect of an Antibody-Derived Peptide in aInternational journal of molecular sciences · 2021Article
- Antifungal activity of MAF-1A peptide against Candida albicans.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- Characterization of the transcriptional response of Candida parapsilosis to the antifungal peptide MAF-1A.PeerJ · 2020Article
- "Tissue barriers · 2019Review
- Interplay between Candida albicans and the antimicrobial peptide armory.Eukaryotic cell · 2014Review
- Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity.The Journal of biological chemistry · 2013Article
- Article
- Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans.PloS one · 2012Article
- Salivary defense proteins: their network and role in innate and acquired oral immunity.International journal of molecular sciences · 2012Review
- The novel Candida albicans transporter Dur31 Is a multi-stage pathogenicity factor.PLoS pathogens · 2012Article
- Endocytosis-mediated vacuolar accumulation of the human ApoE apolipoprotein-derived ApoEdpL-W antimicrobial peptide contributes to its antifungal activity in Candida albicans.Antimicrobial agents and chemotherapy · 2011Article
- Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole.Antimicrobial agents and chemotherapy · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
MUC7 12-mer is a cationic antimicrobial peptide derived from the N-terminal region of human low-molecular-weight salivary mucin. In order to gain new insights into the modes of action of the 12-mer against opportunistic fungal pathogen Candida albicans, we examined changes in the gene expression profile of C. albicans upon exposure to this peptide. Cells at an early logarithmic phase were exposed to 6 muM peptide and grown until an OD(600 nm) of approximately 0.4 was reached. Changes in gene expression were determined by microarray analysis and showed that 19 out of the total of 531 genes, whose expression was elevated in response to the peptide, are regulated by the calcium/calcineurin signalling pathway. Inactivation of this pathway by deletions, or by FK506, caused hypersensitivity to the peptide, demonstrating the importance of this pathway to the defense of C. albicans against the MUC7 peptide. Other differentially expressed genes that were detected include those encoding subunits of proteasome, and genes involved in cell stress, iron metabolism, cell wall maintenance and small-molecule transport. The presented results suggest that the calcium/calcineurin signalling pathway plays a role in the adaptation of C. albicans to the MUC7 antimicrobial peptide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.