ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2010
Blunted heart rate response as a predictor of cardiac death in patients undergoing vasodilator stress technetium-99m sestamibi gated SPECT myocardial perfusion imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Prognostic value of heart rate response during regadenoson stress myocardial perfusion imaging in patients with end stage renal disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Trial
- Blunted heart rate response during dipyridamole stress SPECT is associated with cardiovascular outcomes in an all-comers cohort.BMC cardiovascular disorders · 2026Article
- Article
- Relationship between heart rate response and cardiac innervation in patients with suspected or known coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Early-life persistent vitamin D deficiency-induced cardiovascular dysfunction in mice is mediated by transient receptor potential C channels.The Journal of steroid biochemistry and molecular biology · 2021Article
- The impact of combined cardiopulmonary exercise testing and SPECT myocardial perfusion imaging on downstream evaluation and management.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- The heart rate response to regadenoson in patients with atrial fibrillation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Prognostic value of vasodilator response using rubidium-82 positron emission tomography myocardial perfusion imaging in patients with coronary artery disease.European journal of nuclear medicine and molecular imaging · 2018Observational
- Review of cardiovascular imaging in the journal of nuclear cardiology in 2016: Part 2 of 2-myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- Relationship between gated myocardial perfusion SPECT findings and hemodynamic, electrocardiographic, and heart rate changes after Dipyridamole infusion.The international journal of cardiovascular imaging · 2017Article
- Heart rate response to regadenoson: Making the case for its value in clinical practice.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- The prognostic value of non-perfusion variables obtained during vasodilator stress myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Review
- Patients with reduced heart rate response to adenosine infusion have low myocardial flow reserve in (13)N-ammonia PET studies.The international journal of cardiovascular imaging · 2015Article
- Prognosis in the era of comparative effectiveness research: where is nuclear cardiology now and where should it be?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Review
- The clinical value of single photon emission computed tomography myocardial perfusion imaging in cardiac risk stratification of very elderly patients (≥80 years) with suspected coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- A blunted heart rate response to regadenoson is an independent prognostic indicator in patients undergoing myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
- Cardiovascular imaging in diabetes mellitus.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Review
- Stress-only myocardial perfusion imaging … it is time for a change!Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
- Heart rate response during vasodilator stress myocardial perfusion imaging: Mechanisms and implications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Article
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5 authors at 1 institution in 1 country.
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Abstract
introductionThe prognostic value of a blunted heart rate response (BHR) during ECG-gated vasodilator stress SPECT MPI in relation to ventricular function on long-term cardiovascular events is not well established. We performed this study to evaluate the incremental prognostic value of BHR during pharmacological stress SPECT MPI.
methodsConsecutive patients who underwent dipyridamole stress Tc-99m sestamibi ECG-gated SPECT MPI (without exercise) were identified. The ratio of peak stress heart rate to baseline was noted. If the ratio was <1.20, it was considered blunted (BHR). The images were interpreted using the standard ASNC 17 segment model. Patients were followed up for a mean time period of 2.3 +/- 1.5 years.
resultsSixty-four percent (2,890/4,484) of patients demonstrated BHR during dipyridamole stress testing. Cardiac death, the primary end point, occurred in 6.8% of patients. Patients with BHR had a significantly lower cardiac death-free survival as compared to NO BHR group in total population (83% vs 94%; P < .001) as well as in subgroup with normal ejection fraction (89% vs 96%; P < .001). BHR was an independent predictor of cardiac death after adjusting for multiple clinical, perfusion, and function-related gated SPECT variables.
conclusionBlunted heart rate response during vasodilator stress SPECT MPI is an important prognostic marker for cardiac death.
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