ArticleMedical & biological engineering & computing2010
Multi-scale study of nanoparticle transport and deposition in tissues during an injection process.
Article in Medical & biological engineering & computing, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Numerical investigation of blood flow effects on temperature distribution in pulmonary tumors during magnetic induction hyperthermia.Frontiers in bioengineering and biotechnology · 2025Article
- Numerical simulation study of nanoparticle diffusion in gray matter.Computational and structural biotechnology journal · 2024Article
- Heating Induced Nanoparticle Migration and Enhanced Delivery in Tumor Treatment Using Nanotechnology.Bioengineering (Basel, Switzerland) · 2024Review
- A Novel Experimental Approach to Understand the Transport of Nanodrugs.Materials (Basel, Switzerland) · 2023Article
- Multiscale Modelling of Nanoparticle Distribution in a Realistic Tumour Geometry Following Local Injection.Cancers · 2022Article
- Article
- Modelling of Nanoparticle Distribution in a Spherical Tumour during and Following Local Injection.Pharmaceutics · 2022Article
- Effect of Particle Size and Surface Charge on Nanoparticles Diffusion in the Brain White Matter.Pharmaceutical research · 2022Article
- Insights into Infusion-Based Targeted Drug Delivery in the Brain: Perspectives, Challenges and Opportunities.International journal of molecular sciences · 2022Review
- Nanoparticle Delivery in Prostate Tumors Implanted in Mice Facilitated by Either Local or Whole-Body Heating.Fluids (Basel, Switzerland) · 2021Article
- Theoretical evaluation of enhanced gold nanoparticle delivery to PC3 tumors due to increased hydraulic conductivity or recovered lymphatic function after mild whole body hyperthermia.Medical & biological engineering & computing · 2021Article
- Effect of tissue permeability and drug diffusion anisotropy on convection-enhanced delivery.Drug delivery · 2019Article
- Physiologically based mathematical models of nanomaterials for regulatory toxicology: A review.Computational toxicology (Amsterdam, Netherlands) · 2019Review
- A model-based analysis of tissue targeting efficacy of nanoparticles.Journal of the Royal Society, Interface · 2018Article
- Modeling in vitro cellular responses to silver nanoparticles.Journal of toxicology · 2014Article
- Computational multiscale toxicodynamic modeling of silver and carbon nanoparticle effects on mouse lung function.PloS one · 2013Article
- Adapting source grid parameters to improve the condition of the magnetostatic linear inverse problem of estimating nanoparticle distributions.Medical & biological engineering & computing · 2012Article
- Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities.Critical reviews in biomedical engineering · 2012Review
- Numerical study of nanofluid infusion in deformable tissues for hyperthermia cancer treatments.Medical & biological engineering & computing · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In magnetic nanoparticle hyperthermia for cancer treatment, controlling the nanoparticle distribution delivered in tumors is vital for achieving an optimum distribution of temperature elevations that enables a maximum damage of the tumorous cells while minimizing the heating in the surrounding healthy tissues. A multi-scale model is developed in this study to investigate the spatial distribution of nanoparticles in tissues after nanofluid injection into the extracellular space of tissues. The theoretical study consists of a particle trajectory tracking model that considers particle-surface interactions and a macroscale model for the transport of nanoparticles in the carrier solution in a porous structure. Simulations are performed to examine the effects of a variety of injection parameters and particle properties on the particle distribution in tissues. The results show that particle deposition on the cellular structure is the dominant mechanism that leads to a non-uniform particle distribution. The particle penetration depth is sensitive to the injection rate and surface properties of the particles, but relatively insensitive to the injected volume and concentration of the nanofluid.
Indexed as
Identifiers
20490947What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.