ArticleEuropean journal of applied physiology2010
A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study.
Article in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pooled it
- Sarcopenia and MASLD: novel insights and the future.Nature reviews. Endocrinology · 2026Review
- Review
- TheMetabolites · 2024Article
- [Genetics in sports-muscle injuries].Orthopadie (Heidelberg, Germany) · 2023Review
- Review
- Genes and Athletic Performance: The 2023 Update.Genes · 2023Review
- Editorial: Aging, Body Composition, and Cognitive Decline: Shared and Unique Characteristics.The journal of nutrition, health & aging · 2023Article
- Polygenic Models Partially Predict Muscle Size and Strength but Not Low Muscle Mass in Older Women.Genes · 2022Article
- Article
- Article
- The Association of Multiple Gene Variants with Ageing Skeletal Muscle Phenotypes in Elderly Women.Genes · 2020Article
- Association between single-nucleotide polymorphisms in growth factor genes and quality of life in men with prostate cancer and the general population.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Genetic Variation and Insulin Resistance in Middle-Aged Chinese Men.Annals of human genetics · 2015Article
- The polymorphism of Insulin-like growth factor-I (IGF-I) is related to osteoporosis and bone mineral density in postmenopausal population.Pakistan journal of medical sciences · 2014Article
- Highlights from the functional single nucleotide polymorphisms associated with human muscle size and strength or FAMuSS study.BioMed research international · 2013Article
- An overview of the contribution of fatness and fitness factors, and the role of exercise, in the formation of health status for individuals who are overweight.Journal of diabetes and metabolic disorders · 2012Article
- Integration of immunity with physical and cognitive function in definitions of successful aging.Aging and disease · 2012Article
- A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme.PloS one · 2012Article
- Linking genes with exercise: where is the cut-off?European journal of applied physiology · 2010Article
Corrections and comments
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Authors and funding
19 authors at 16 institutions in 2 countries.
Funding
Abstract
Previous studies have reported associations of polymorphisms in the IGF1 gene with phenotypes of body composition (BC). The purpose of this study was to identify phenotypes of BC and physical function that were associated with the IGF1 promoter polymorphism (rs35767, -C1245T). Subjects from the Health, Aging, and Body Composition Study, white males and females (n = 925/836) and black males and females (533/705) aged 70-79 years were genotyped for the polymorphism. Phenotypes of muscle size and function, bone mineral density, and BC were analyzed for associations with this polymorphism. To validate and compare these findings, a cohort of young (mean age = 24.6, SD = 5.9) white men and women (n = 173/296) with similar phenotypic measurements were genotyped. An association with BC was identified in elderly females when significant covariates (physical activity, age, smoking status, body mass index) were included. White women with C/C genotype had 3% more trunk fat and 2% more total fat than those with C/T (P < 0.05). Black women with C/C genotype had 3% less total lean mass and 3% less muscle mass than their T/T counterparts (P < 0.05). Associations were identified with muscle strength in white women (P < 0.01) that were in agreement with the C/C genotype having lower muscle function. Thus, in an elderly population but not a young population, a polymorphism in the IGF1 gene may be predictive of differences in body composition, primarily in black females.
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