ArticleJournal of clinical biochemistry and nutrition2010
H. pylori-Eradication Therapy Increases RUNX3 Expression in the Glandular Epithelial Cells in Enlarged-Fold Gastritis.
Article in Journal of clinical biochemistry and nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- The simplified Kyoto classification score is consistent with the ABC method of classification as a grading system for endoscopic gastritis.Journal of clinical biochemistry and nutrition · 2021Article
- A single nucleotide polymorphism inJournal of clinical biochemistry and nutrition · 2021Article
- Endoscopic Kyoto classification ofWorld journal of gastroenterology · 2020Review
- Effects of patient age and choice of antisecretory agent on success of eradication therapy forJournal of clinical biochemistry and nutrition · 2017Article
- Characteristics of gastric cancer detected within 1 year after successful eradication ofJournal of clinical biochemistry and nutrition · 2016Article
- Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions.World journal of clinical oncology · 2015Review
- Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy.BioMed research international · 2015Review
- The role of microRNA in gastric malignancy.International journal of molecular sciences · 2013Review
- Helicobacter pylori infection in functional dyspepsia.Nature reviews. Gastroenterology & hepatology · 2013Review
- Dual therapy for third-line Helicobacter pylori eradication and urea breath test prediction.World journal of gastroenterology · 2012Article
- Roles of oxidative stress in stomach disorders.Journal of clinical biochemistry and nutrition · 2012Article
- Regulation of the actin cytoskeleton in Helicobacter pylori-induced migration and invasive growth of gastric epithelial cells.Cell communication and signaling : CCS · 2011Article
- New insights into the inactivation of gastric tumor suppressor RUNX3: the role of H. pylori infection.Journal of cellular biochemistry · 2011Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori (HP)-eradication therapy increases Runt domain transcription factor 3 (RUNX3) expression in the glandular epithelial cells in enlarged-fold gastritis. The aim of this study is to evaluate expression of the RUNX3 protein, the product of a gastric tumor suppression gene, and mutagenic oxidative stress in human gastric mucosal specimens obtained from patients with HP-induced enlarged-fold gastritis. Methods. RUNX3 expression was immunohistochemically scored and the degree of the mucosal oxidative stress was directly measured by the chemiluminescense (ChL) assay in the biopsy specimens. Results. RUNX3 expression was detected in the gastric epithelial cells. HP-eradication significantly increased RUNX3 expression in the glandular epithelium of the corpus, however, no change was observed in those of the antrum. A fourfold higher mucosal ChL value was observed in the corpus as compared with that in the antrum. HP-eradication significantly decreased the mucosal ChL values in both portions of the stomach to nearly undetectable levels. Conclusion. The glandular epithelium is exposed to a high level of carcinogenic oxidative stress and shows low levels of expression of the tumor suppressive molecule, RUNX3; however, this expression was restored after HP-eradication, suggesting the high risk of carcinogenesis associated with HP-induced enlarged-fold gastritis of the corpus.
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