ArticleAJR. American journal of roentgenology2010
Breast cancers not detected at MRI: review of false-negative lesions.
Article in AJR. American journal of roentgenology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Comparison of Diagnostic Test Accuracy of Cone-Beam Breast Computed Tomography and Digital Breast Tomosynthesis for Breast Cancer: A Systematic Review and Meta-Analysis Approach.Sensors (Basel, Switzerland) · 2022Pooled it
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- Case Report: Mammary Paget's disease with multifocal microinvasive carcinoma and extensive lymph node metastasis: therapeutic challenges and insights from a case of stage pT1mic pN3c cM0.Frontiers in oncology · 2025Article
- Injecting hope: the potential of intratumoral immunotherapy for locally advanced and metastatic cancer.Frontiers in immunology · 2024Review
- Quantitative evaluation of Kaiser score in diagnosing breast dynamic contrast-enhanced magnetic resonance imaging for patients with high-grade background parenchymal enhancement.Quantitative imaging in medicine and surgery · 2023Article
- Caveat Emptor: Commercialized Manganese Oxide Nanoparticles Exhibit Unintended Properties.ACS omega · 2023Article
- Non-enhancing malignant lesions of the breast: A case report and review of literature.Heliyon · 2023Article
- Contrast enhanced mammography: focus on frequently encountered benign and malignant diagnoses.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Review
- The Frequency and Causes of Not-Detected Breast Malignancy in Dynamic Contrast-Enhanced MRI.Diagnostics (Basel, Switzerland) · 2022Article
- Review
- Missed Breast Cancers on MRI in High-Risk Patients: A Retrospective Case-Control Study.Tomography (Ann Arbor, Mich.) · 2022Article
- Fusion of high b-value diffusion-weighted and unenhanced T1-weighted images to diagnose invasive breast cancer: factors associated with false-negative results.European radiology · 2021Article
- Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Observational
- Which clinical, radiological, histological, and molecular parameters are associated with the absence of enhancement of known breast cancers with Contrast Enhanced Digital Mammography (CEDM)?Breast (Edinburgh, Scotland) · 2020Article
- Fully automatic classification of breast MRI background parenchymal enhancement using a transfer learning approach.Medicine · 2020Article
- Can Magnetic Resonance Imaging Replace Mammography and Ultrasonography for the Detection of Breast Lesions?Cureus · 2020Article
- Diagnostic value of molybdenum target combined with DCE-MRI in different types of breast cancer.Oncology letters · 2019Article
- The frequency of missed breast cancers in women participating in a high-risk MRI screening program.Breast cancer research and treatment · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of our study was to determine the sensitivity of cancer detection at breast MRI using current imaging techniques and to evaluate the characteristics of lesions with false-negative examinations. MATERIALS AND
methodsTwo hundred seventeen patients with 222 newly diagnosed breast cancers or highly suspicious breast lesions that were subsequently shown to be malignant underwent breast MRI examinations for staging. Two breast imaging radiologists performed a consensus review of the breast MRI examinations. The absence of perceptible contrast enhancement at the expected site was considered to be a false-negative MRI. Histology of all lesions was reviewed by an experienced breast pathologist.
resultsEnhancement was observed in 213 (95.9%) of the 222 cancer lesions. Of the nine lesions without visible enhancement, two lesions were excluded because the entire tumor had been excised at percutaneous biopsy performed before the MRI examination and no residual tumor was noted on the final histology. The overall sensitivity of MRI for the known cancers was 96.8% (213/220); for invasive cancer, 98.3% (176/179); and for ductal carcinoma in situ, 90.2% (37/41).
conclusionIn a population of 220 sequentially diagnosed breast cancer lesions, we found seven (3.2%) MRI-occult cancers, fewer than seen in other published studies. Small tumor size and diffuse parenchymal enhancement were the principal reasons for these false-negative results. Although the overall sensitivity of cancer detection was high (96.8%), it should be emphasized that a negative MRI should not influence the management of a lesion that appears to be of concern on physical examination or on other imaging techniques.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.