ArticleGenome research2010
Genome-wide gene expression regulation as a function of genotype and age in C. elegans.
Article in Genome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed.
- Association of the expression of 5-FU biomarkers with aging and prognosis in elderly patients with lung cancer treated with S-1 adjuvant chemotherapy: Follow-up results of the Setouchi Lung Cancer Group Study 1201.Molecular and clinical oncology · 2025Article
- The regulatory architecture of gene expression variation in Caenorhabditis elegans revealed by multi-strain allele-specific analysis.Genetics · 2025Article
- Genetic mapping of lifespan and mitochondrial stress response inbioRxiv : the preprint server for biology · 2025Article
- The regulatory architecture of gene expression variation inbioRxiv : the preprint server for biology · 2025Article
- Plasma proteome variation and its genetic determinants in children and adolescents.Nature genetics · 2025Article
- eQTL mapping in transgenic alpha-synuclein carrying Caenorhabditis elegans recombinant inbred lines.Human molecular genetics · 2024Article
- High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan.Cell reports · 2024Article
- Omics data analysis reveals the system-level constraint on cellular amino acid composition.Synthetic and systems biotechnology · 2024Article
- Quantifying transcriptome diversity: a review.Briefings in functional genomics · 2024Review
- The effect of developmental variation on expression QTLs in a multi parental Caenorhabditis elegans population.G3 (Bethesda, Md.) · 2024Article
- High-content phenotypic analysis ofbioRxiv : the preprint server for biology · 2024Article
- Beyond the reference: gene expression variation and transcriptional response to RNA interference in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- Cryptic genetic variation of expression quantitative trait locus architecture revealed by genetic perturbation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- Beyond the reference: gene expression variation and transcriptional response to RNAi inbioRxiv : the preprint server for biology · 2023Article
- Plasticity of maternal environment-dependent expression-QTLs of tomato seeds.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- The impact of species-wide gene expression variation on Caenorhabditis elegans complex traits.Nature communications · 2022Article
- Article
- Review
- From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.Trends in genetics : TIG · 2021Review
- The genetics of gene expression in a Caenorhabditis elegans multiparental recombinant inbred line population.G3 (Bethesda, Md.) · 2021Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Gene expression becomes more variable with age, and it is widely assumed that this is due to a decrease in expression regulation. But currently there is no understanding how gene expression regulatory patterns progress with age. Here we explored genome-wide gene expression variation and regulatory loci (eQTL) in a population of developing and aging C. elegans recombinant inbred worms. We found almost 900 genes with an eQTL, of which almost half were found to have a genotype-by-age effect ((gxa)eQTL). The total number of eQTL decreased with age, whereas the variation in expression increased. In developing worms, the number of genes with increased expression variation (1282) was similar to the ones with decreased expression variation (1328). In aging worms, the number of genes with increased variation (1772) was nearly five times higher than the number of genes with a decreased expression variation (373). The number of cis-acting eQTL in juveniles decreased by almost 50% in old worms, whereas the number of trans-acting loci decreased by approximately 27%, indicating that cis-regulation becomes relatively less frequent than trans-regulation in aging worms. Of the 373 genes with decreased expression level variation in aging worms, approximately 39% had an eQTL compared with approximately 14% in developing worms. (gxa)eQTL were found for approximately 21% of these genes in aging worms compared with only approximately 6% in developing worms. We highlight three examples of linkages: in young worms (pgp-6), in old worms (daf-16), and throughout life (lips-16). Our findings demonstrate that eQTL patterns are strongly affected by age, and suggest that gene network integrity declines with age.
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