ArticleAJNR. American journal of neuroradiology2010
Regional distribution and clinical correlates of white matter structural damage in Huntington disease: a tract-based spatial statistics study.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Consistent neurodegeneration and its association with clinical progression in Huntington's disease: a coordinate-based meta-analysis.Neuro-degenerative diseases · 2013Pooled it
- Grey and white matter abnormalities in minimal hepatic encephalopathy: a study combining voxel-based morphometry and tract-based spatial statistics.European radiology · 2013Trial
- White matter changes in patients with friedreich ataxia after treatment with erythropoietin.Journal of neuroimaging : official journal of the American Society of NeuroimagingTrial
- Myelin Lipid Alterations in Neurodegenerative Diseases: Landscape and Pathogenic Implications.Antioxidants & redox signaling · 2024Review
- The contribution of preclinical magnetic resonance imaging and spectroscopy to Huntington's disease.Frontiers in aging neuroscience · 2024Review
- White Matter Microstructure Changes Revealed by Diffusion Kurtosis and Diffusion Tensor Imaging in Mutant Huntingtin Gene Carriers.Journal of Huntington's disease · 2024Article
- Progressive alterations in white matter microstructure across the timecourse of Huntington's disease.Brain and behavior · 2023Article
- Mutation-related magnetization-transfer, not axon density, drives white matter differences in premanifest Huntington disease: Evidence from in vivo ultra-strong gradient MRI.Human brain mapping · 2022Article
- Classification of Huntington's Disease Stage with Features Derived from Structural and Diffusion-Weighted Imaging.Journal of personalized medicine · 2022Article
- Early white matter pathology in the fornix of the limbic system in Huntington disease.Acta neuropathologica · 2021Article
- Extreme capsule is a bottleneck for ventral pathway.IBRO neuroscience reports · 2021Review
- Time will tell: Decision making in premanifest and manifest Huntington's disease.Brain and behavior · 2020Article
- Diffusion imaging in Huntington's disease: comprehensive review.Journal of neurology, neurosurgery, and psychiatry · 2020Review
- Dissecting the Fornix in Basic Memory Processes and Neuropsychiatric Disease: A Review.Brain connectivity · 2020Review
- White and Gray Matter Abnormalities in Manifest Huntington's Disease: Cross-Sectional and Longitudinal Analysis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Increased white matter diffusivity associated with phantom limb pain.The Korean journal of pain · 2019Article
- Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma.PloS one · 2019Article
- Distinctive Patterns of Seizure-Related White Matter Alterations in Right and Left Temporal Lobe Epilepsy.Frontiers in neurology · 2019Article
- Natural biological variation of white matter microstructure is accentuated in Huntington's disease.Human brain mapping · 2018Article
- Neuroimaging in Dementia.Seminars in neurology · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeHD entails damage of the WM. Our aim was to explore in vivo the regional volume and microstructure of the brain WM in HD and to correlate such findings with clinical status of the patients. MATERIALS AND
methodsFifteen HD gene carriers in different clinical stages of the disease and 15 healthy controls were studied with T1-weighted images for VBM and DTI for TBSS. Maps of FA, MD, and λ∥ and λ⊥ were reconstructed.
resultsCompared with controls, in addition to neostriatum and cortical GM volume loss, individuals with HD showed volume loss in the genu of the internal capsule and subcortical frontal WM bilaterally, the right splenium of the corpus callosum, and the left corona radiata. TBSS revealed symmetrically decreased FA in the corpus callosum, fornix, external/extreme capsule, inferior fronto-occipital fasciculus, and inferior longitudinal fasciculus. Areas of increased MD were more extensive and included arciform fibers of the cerebral hemispheres and cerebral peduncles. Increase of the λ∥ and a comparatively more pronounced increase of the λ⊥ underlay the decreased FA of the WM in HD. Areas of WM atrophy, decreased FA, and increased MD correlated with the severity of the motor and cognitive dysfunction, whereas only the areas with increased MD correlated with disease duration.
conclusionsMicrostructural damage accompanies volume decrease of the WM in HD and is correlated with the clinical deficits and disease duration. MR imaging-based measures could be considered as a biomarker of neurodegeneration in HD gene carriers.
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