ArticleMicrobiology (Reading, England)2010
Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi.
Article in Microbiology (Reading, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- A Chimeric ORF Fusion Phenotypic Reporter forJournal of fungi (Basel, Switzerland) · 2024Article
- Illuminating the Cryptococcus neoformans species complex: unveiling intracellular structures with fluorescent-protein-based markers.Genetics · 2024Article
- Crucial Involvement of Heme Biosynthesis in Vegetative Growth, Development, Stress Response, and Fungicide Sensitivity ofInternational journal of molecular sciences · 2024Article
- Genome-Wide Characterization of Light-Regulated Gene Expression inInternational journal of molecular sciences · 2023Article
- Light Stress in Yeasts: Signaling and Responses in Creatures of the Night.International journal of molecular sciences · 2023Review
- Review
- A three-gene cluster in Trichoderma reesei reveals a potential role of dmm2 in DNA repair and cellulase production.Biotechnology for biofuels and bioproducts · 2022Article
- Impact of the White Collar Photoreceptor WcoA on theFrontiers in microbiology · 2020Article
- The Blue-Light PhotoreceptorApplied and environmental microbiology · 2019Article
- Article
- The contribution of the White Collar complex to Cryptococcus neoformans virulence is independent of its light-sensing capabilities.Fungal genetics and biology : FG & B · 2018Article
- Light-regulated promoters for tunable, temporal, and affordable control of fungal gene expression.Applied microbiology and biotechnology · 2018Review
- The molecular mechanisms of Monascus purpureus M9 responses to blue light based on the transcriptome analysis.Scientific reports · 2017Article
- Regulators of plant biomass degradation in ascomycetous fungi.Biotechnology for biofuels · 2017Review
- White collar 1-induced photolyase expression contributes to UV-tolerance of Ustilago maydis.MicrobiologyOpen · 2016Article
- Virulence-Associated Enzymes of Cryptococcus neoformans.Eukaryotic cell · 2015Review
- Fungal photobiology: visible light as a signal for stress, space and time.Current genetics · 2015Review
- Evolving a 24-hr oscillator in budding yeast.eLife · 2014Article
- 'Division of labour' in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak.Nature communications · 2014Article
- Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.Cold Spring Harbor perspectives in medicine · 2014Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Light is a universal signal perceived by organisms, including fungi, in which light regulates common and unique biological processes depending on the species. Previous research has established that conserved proteins, originally called White collar 1 and 2 from the ascomycete Neurospora crassa, regulate UV/blue light sensing. Homologous proteins function in distant relatives of N. crassa, including the basidiomycetes and zygomycetes, which diverged as long as a billion years ago. Here we conducted microarray experiments on the basidiomycete fungus Cryptococcus neoformans to identify light-regulated genes. Surprisingly, only a single gene was induced by light above the commonly used twofold threshold. This gene, HEM15, is predicted to encode a ferrochelatase that catalyses the final step in haem biosynthesis from highly photoreactive porphyrins. The C. neoformans gene complements a Saccharomyces cerevisiae hem15Delta strain and is essential for viability, and the Hem15 protein localizes to mitochondria, three lines of evidence that the gene encodes ferrochelatase. Regulation of HEM15 by light suggests a mechanism by which bwc1/bwc2 mutants are photosensitive and exhibit reduced virulence. We show that ferrochelatase is also light-regulated in a white collar-dependent fashion in N. crassa and the zygomycete Phycomyces blakesleeanus, indicating that ferrochelatase is an ancient target of photoregulation in the fungal kingdom.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.