ArticleMolecular microbiology2010
Genetic analysis of petrobactin transport in Bacillus anthracis.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Structural basis of FatB-mediated iron uptake via tyrosine/histidine direct coordination accompanying long-distance domain reorganization.Nature communications · 2026Article
- Exploring the Biological Pathways of Siderophores and Their Multidisciplinary Applications: A Comprehensive Review.Molecules (Basel, Switzerland) · 2024Review
- Article
- Phylogenetic determinants of toxin gene distribution in genomes of Brevibacillus laterosporus.Genomics · 2020Article
- Heme catabolism in the causative agent of anthrax.Molecular microbiology · 2019Article
- Article
- Transcriptional response of Clostridium difficile to low iron conditions.Pathogens and disease · 2018Article
- Petrobactin Is Exported frommBio · 2017Article
- Global gene expression by Bacillus anthracis during growth in mammalian blood.Pathogens and disease · 2015Article
- Functional and structural analysis of the siderophore synthetase AsbB through reconstitution of the petrobactin biosynthetic pathway from Bacillus anthracis.The Journal of biological chemistry · 2012Article
- Multiple ABC transporters are involved in the acquisition of petrobactin in Bacillus anthracis.Molecular microbiology · 2012Article
- Membrane topology of the Bacillus anthracis GerH germinant receptor proteins.Journal of bacteriology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Iron acquisition mechanisms play an important role in the pathogenesis of many infectious microbes. In Bacillus anthracis, the siderophore petrobactin is required for both growth in iron-depleted conditions and for full virulence of the bacterium. Here we demonstrate the roles of two putative petrobactin binding proteins FatB and FpuA (encoded by GBAA5330 and GBAA4766 respectively) in B. anthracis iron acquisition and pathogenesis. Markerless deletion mutants were created using allelic exchange. The Delta fatB strain was capable of wild-type levels of growth in iron-depleted conditions, indicating that FatB does not play an essential role in petrobactin uptake. In contrast, Delta fpuA bacteria exhibited a significant decrease in growth under low-iron conditions when compared with wild-type bacteria. This mutant could not be rescued by the addition of exogenous purified petrobactin. Further examination of this strain demonstrated increased levels of petrobactin accumulation in the culture supernatants, suggesting no defect in siderophore synthesis or export but, instead, an inability of Delta fpuA to import this siderophore. Delta fpuA spores were also significantly attenuated in a murine model of inhalational anthrax. These results provide the first genetic evidence demonstrating the role of FpuA in petrobactin uptake.
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