ArticleMolecular microbiology2010
The alternative oxidase (AOX) gene in Vibrio fischeri is controlled by NsrR and upregulated in response to nitric oxide.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Review
- Flagella are required to coordinately activate competition and host colonization factors in response to a mechanical signal.bioRxiv : the preprint server for biology · 2024Article
- DksA, ppGpp, and RegAB Regulate Nitrate Respiration in Paracoccus denitrificans.Journal of bacteriology · 2023Article
- Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?The Biochemical journal · 2022Review
- Complex Interplay of Heme-Copper Oxidases with Nitrite and Nitric Oxide.International journal of molecular sciences · 2022Review
- How Microbes Defend Themselves From Incoming Hydrogen Peroxide.Frontiers in immunology · 2021Review
- Animal development in the microbial world: The power of experimental model systems.Current topics in developmental biology · 2021Review
- The response of Sphingopyxis granuli strain TFA to the hostile anoxic condition.Scientific reports · 2019Article
- CytochromesApplied and environmental microbiology · 2018Article
- Alternative Oxidase Activity Reduces Stress in Vibrio fischeri Cells Exposed to Nitric Oxide.Journal of bacteriology · 2018Article
- Transcriptional characterization of Vibrio fischeri during colonization of juvenile Euprymna scolopes.Environmental microbiology · 2017Article
- An Expanded Transposon Mutant Library Reveals that Vibrio fischeri δ-Aminolevulinate Auxotrophs Can Colonize Euprymna scolopes.Applied and environmental microbiology · 2017Article
- Impact and Influence of the NaturalFrontiers in microbiology · 2016Review
- A conserved chemical dialog of mutualism: lessons from squid and vibrio.Microbes and infection · 2016Review
- Regulation of Bioluminescence in Photobacterium leiognathi Strain KNH6.Journal of bacteriology · 2015Article
- Article
- Regulation of nitrite resistance of the cytochrome cbb3 oxidase by cytochrome c ScyA in Shewanella oneidensis.MicrobiologyOpen · 2015Article
- Gasotransmitters, poisons, and antimicrobials: it's a gas, gas, gas!F1000prime reports · 2013Article
- Article
- Global transcriptional control by NsrR in Bacillus subtilis.Journal of bacteriology · 2012Article
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6 authors at 3 institutions in 1 country.
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Abstract
Alternative oxidase (AOX) is a respiratory oxidase found in certain eukaryotes and bacteria; however, its role in bacterial physiology is unclear. Exploiting the genetic tractability of the bacterium Vibrio fischeri, we explore the regulation of aox expression and AOX function. Using quantitative PCR and reporter assays, we demonstrate that aox expression is induced in the presence of nitric oxide (NO), and that the NO-responsive regulatory protein NsrR mediates the response. We have identified key amino acid residues important for NsrR function and experimentally confirmed a bioinformatically predicted NsrR binding site upstream of aox. Microrespirometry demonstrated that oxygen consumption by V. fischeri CydAB quinol oxidase is inhibited by NO treatment, whereas oxygen consumption by AOX is less sensitive to NO. NADH oxidation assays using inverted membrane vesicles confirmed that NO directly inhibits CydAB, and that AOX is resistant to NO inhibition. These results indicate a role for V. fischeri AOX in aerobic respiration during NO stress.
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