ArticleMolecular microbiology2010
A multi-protein complex from Myxococcus xanthus required for bacterial gliding motility.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 95 citations in OpenAlex.
- Milestones in the development ofJournal of bacteriology · 2025Review
- Structural model of a bacterial focal adhesion complex.Communications biology · 2025Article
- A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall.eLife · 2024Article
- A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall.bioRxiv : the preprint server for biology · 2024Article
- A molecular switch controls assembly of bacterial focal adhesions.Science advances · 2024Article
- Unmasking of the von Willebrand A-domain surface adhesin CglB at bacterial focal adhesions mediates myxobacterial gliding motility.Science advances · 2023Article
- Mathematical modeling of mechanosensitive reversal control inFrontiers in microbiology · 2023Article
- Flagellar Motor Transformed: Biophysical Perspectives of theFrontiers in microbiology · 2022Article
- Complete Genome Sequence of the Nonmotile Myxococcus xanthus Strain NM.Microbiology resource announcements · 2021Article
- Protein-protein interaction network controlling establishment and maintenance of switchable cell polarity.PLoS genetics · 2020Article
- Identification and characterization of novel filament-forming proteins in cyanobacteria.Scientific reports · 2020Article
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- Second messengers and divergent HD-GYP phosphodiesterases regulate 3',3'-cGAMP signaling.Molecular microbiology · 2020Article
- A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays.PLoS genetics · 2019Article
- Spatial control of the GTPase MglA by localized RomR-RomX GEF and MglB GAP activities enables Myxococcus xanthus motility.Nature microbiology · 2019Article
- MotAB-like machinery drives the movement of MreB filaments during bacterial gliding motility.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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- Novel mechanisms power bacterial gliding motility.Molecular microbiology · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Myxococcus xanthus moves by gliding motility powered by Type IV pili (S-motility) and a second motility system, A-motility, whose mechanism remains elusive despite the identification of approximately 40 A-motility genes. In this study, we used biochemistry and cell biology analyses to identify multi-protein complexes associated with A-motility. Previously, we showed that the N-terminal domain of FrzCD, the receptor for the frizzy chemosensory pathway, interacts with two A-motility proteins, AglZ and AgmU. Here we characterized AgmU, a protein that localized to both the periplasm and cytoplasm. On firm surfaces, AgmU-mCherry colocalized with AglZ as distributed clusters that remained fixed with respect to the substratum as cells moved forward. Cluster formation was favoured by hard surfaces where A-motility is favoured. In contrast, AgmU-mCherry clusters were not observed on soft agar surfaces or when cells were in large groups, conditions that favour S-motility. Using glutathione-S-transferase affinity chromatography, AgmU was found to interact either directly or indirectly with multiple A-motility proteins including AglZ, AglT, AgmK, AgmX, AglW and CglB. These proteins, important for the correct localization of AgmU and AglZ, appear to be organized as a motility complex, spanning the cytoplasm, inner membrane and the periplasm. Identification of this complex may be important for uncovering the mechanism of A-motility.
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