Trial reportMolecular nutrition & food research2010
Disposition of hop prenylflavonoids in human breast tissue.
Trial report in Molecular nutrition & food research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- The Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data.Molecular nutrition & food research · 2026Trial
- Liquid Chromatography/Tandem Mass Spectrometry Analysis ofAntioxidants (Basel, Switzerland) · 2024Article
- Tissue distribution and pharmacokinetics of isoxanthohumol from hops in rodents.Food science & nutrition · 2024Article
- Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells.Materials (Basel, Switzerland) · 2022Article
- 8-Prenylnaringenin tissue distribution and pharmacokinetics in mice and its binding to human serum albumin and cellular uptake in human embryonic kidney cells.Food science & nutrition · 2022Article
- Herbal Products Used in Menopause and for Gynecological Disorders.Molecules (Basel, Switzerland) · 2021Review
- Promotion effects of flavonoids on browning induced by enzymatic oxidation of tyrosinase: structure-activity relationship.RSC advances · 2021Article
- Flavonoids as Phytoestrogenic Components of Hops and Beer.Molecules (Basel, Switzerland) · 2020Review
- Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives.International journal of molecular sciences · 2020Review
- The Multiple Biological Targets of Hops and Bioactive Compounds.Chemical research in toxicology · 2019Review
- Highly Cancer Selective Antiproliferative Activity of Natural Prenylated Flavonoids.Molecules (Basel, Switzerland) · 2018Article
- Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops.Molecules (Basel, Switzerland) · 2018Review
- The Hop Polyphenols Xanthohumol and 8-Prenyl-Naringenin Antagonize the Estrogenic Effects ofFrontiers in nutrition · 2018Article
- Modulation of estrogen synthesis and metabolism by phytoestrogensToxicology research · 2017Review
- Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats.The Journal of steroid biochemistry and molecular biology · 2017Article
- Does consumption of red grapefruit juice alter naringenin concentrations in milk produced by breastfeeding mothers?PloS one · 2017Article
- Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16.European journal of nutrition · 2016Article
- Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement.Biomedical chromatography : BMC · 2014Article
- Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2014Article
- Botanical modulation of menopausal symptoms: mechanisms of action?Planta medica · 2013Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Hop-derived products may contain xanthohumol (XN), isoxanthohumol (IX), and the potent phytoestrogen 8-prenylnaringenin (8-PN). To evaluate the potential health effects of these prenylflavonoids on breast tissue, their concentration, nature of metabolites, and biodistribution were assessed and compared with 17beta-estradiol (E(2)) exposure. In this dietary intervention study, women were randomly allocated to hop (n=11; 2.04 mg XN, 1.20 mg IX, and 0.1 mg 8-PN per supplement) or control (n=10). After a run-in of >or=4 days, three supplements were taken daily for 5 days preceding an aesthetic breast reduction. Blood and breast biopsies were analyzed using HPLC-ESI-MS/MS. Upon hop administration, XN and IX concentrations ranged between 0.72 and 17.65 nmol/L and 3.30 and 31.50 nmol/L, and between 0.26 and 5.14 pmol/g and 1.16 and 83.67 pmol/g in hydrolyzed serum and breast tissue, respectively. 8-PN however, was only detected in samples of moderate and strong 8-PN producers (0.43-7.06 nmol/L and 0.78-4.83 pmol/g). Phase I metabolism appeared to be minor (approximately 10%), whereas extensive glucuronidation was observed (> 90%). Total prenylflavonoids showed a breast adipose/glandular tissue distribution of 38/62 and their derived E(2)-equivalents were negligible compared with E(2) in adipose (384.6+/-118.8 fmol/g, p=0.009) and glandular (241.6+/-93.1 fmol/g, p<0.001) tissue, respectively. Consequently, low doses of prenylflavonoids are unlikely to elicit estrogenic responses in breast tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.