ArticleJournal of clinical laboratory analysis2010
Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease.
Article in Journal of clinical laboratory analysis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.Molecular psychiatry · 2013Pooled it
- Investigation of base excision repair gene variants in late-onset Alzheimer's disease.PloS one · 2019Trial
- Trial
- Tipping the PARylation scale: Dysregulation of PAR signaling in Huntington and neurodegenerative diseases.Journal of Huntington's disease · 2025Review
- Neuroprotective Effects of PARP Inhibitors inCells · 2022Article
- Contributions of DNA Damage to Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Review
- Sex differences in Alzheimer's disease: Understanding the molecular impact.Brain research · 2019Review
- Modulation of brain tumor risk by genetic SNPs in PARP1gene: Hospital based case control study.PloS one · 2019Article
- Article
- Genome instability in Alzheimer disease.Mechanisms of ageing and development · 2017Review
- The epigenetics of aging and neurodegeneration.Progress in neurobiology · 2015Review
- Polymorphism of the DNA base excision repair genes in keratoconus.International journal of molecular sciences · 2014Article
- Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia.Journal of assisted reproduction and genetics · 2014Article
- Association of three SNPs in the PARP-1 gene with Hashimoto's thyroiditis.Human genome variation · 2014Article
- Therapeutic applications of PARP inhibitors: anticancer therapy and beyond.Molecular aspects of medicine · 2013Review
- Deoxyribonucleic acid repair gene X-ray repair cross-complementing group 1 polymorphisms and non-carcinogenic disease risk in different populations: A meta-analysis.Indian journal of human genetics · 2013Article
- The role of Beta-adrenergic receptor blockers in Alzheimer's disease: potential genetic and cellular signaling mechanisms.American journal of Alzheimer's disease and other dementias · 2013Review
- Multimodal brain image analysis : third International Workshop, MBIA 2013, held in conjunction with MICCAI 2013, Nagoya, Japan, September 22, 2013 : proceedings. MBIA (Workshop) (3rd : 2013 : Nagoya-shi, Japan) · 2013Article
- Activation of PARP by oxidative stress induced by β-amyloid: implications for Alzheimer's disease.Neurochemical research · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyloid peptide is thought to play a critical role in neuronal death in Alzheimer's disease (AD), most likely through oxidative stress. Free radical-related injury leads to DNA breaks, which subsequently activates the repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1). In this study, the relationship between genetic variants situated at the PARP-1 gene and AD development was investigated. We performed a case and control study from a Taiwanese population enrolled 120 AD patients and 111 healthy controls by using a polymerase chain reaction restriction fragment length polymorphism approach for two PARP-1 exonic polymorphisms, 414C/T (rs1805404) and 2456T/C (rs1136410), corresponding to protein residues at positions 81Asp/Asp and 762Val/Ala. There were no significant differences in allele or genotype frequencies for either PARP-1 gene variant between the case and control groups; however, upon analysis of the haplotype distribution, four haplotypes (Hts) were identified. We found that the distributions of Ht3-TT and Ht4-CC were significantly associated with an increased risk of AD (P<0.0001), whereas the Ht1-TC haplotype showed a protective effect for cases compared with the control group (P<0.05). These results reveal that the PARP-1 gene is highly associated with AD susceptibility and might contribute to a critical mechanism that mediates cell survival or death as a response to cytotoxic stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.