ArticleEuropean journal of immunology2010
The dynamic TCRδ: TCRδ chains in the amphibian Xenopus tropicalis utilize antibody-like V genes.
Article in European journal of immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- Immunoglobulin genetics of a model squamate reptile, Tiliqua rugosa.Immunogenetics · 2025Article
- Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon.Science advances · 2025Article
- Unique TCR loci architecture in newts: TRA and TRD separation inFrontiers in immunology · 2025Article
- Genomic characterization of the T-cell receptor loci inFrontiers in immunology · 2025Article
- The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms.Immunological reviews · 2024Review
- Macroevolution of avian T cell receptor C segments using genomic data.Immunogenetics · 2023Article
- Comparative genomics of the T cell receptor μ locus in marsupials and monotremes.Immunogenetics · 2023Article
- The amphibian immune system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Characterization of immunoglobulinFrontiers in immunology · 2023Article
- Comparison of Reptilian Genomes Reveals Deletions Associated with the Natural Loss of γδ T Cells in Squamates.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Lost structural and functional inter-relationships between Ig and TCR loci in mammals revealed in sharks.Immunogenetics · 2021Review
- Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids.Frontiers in immunology · 2021Article
- TR Locus Annotation and Characteristics ofFrontiers in immunology · 2021Article
- Nurse shark T-cell receptors employ somatic hypermutation preferentially to alter alpha/delta variable segments associated with alpha constant region.European journal of immunology · 2020Article
- Inferring the "Primordial Immune Complex": Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- A cold-blooded view of adaptive immunity.Nature reviews. Immunology · 2018Review
- Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus.eLife · 2018Article
- Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.Cell reports · 2017Article
- A comprehensive analysis of the germline and expressed TCR repertoire in White Peking duck.Scientific reports · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The content and organization of the Xenopus tropicalis TCRα/δ locus was determined. This locus is highly conserved among tetrapods, with the genes encoding the TCRδ chains embedded with those encoding TCRα. However, the frog TCRα/δ is unusual in that it contains V genes that appear indistinguishable from those in the IgH locus (VH). These V genes, termed VHδ, make up 70% of the V genes at the TCRδ locus and are expressed exclusively in TCRδ chains. Finding TCRδ chains that use antibody-like V domains in frogs is similar to the situation in shark TCRδ variants and TCRμ in marsupials. These results suggest that such unconventional TCR may be more widespread across vertebrate lineages than originally thought and raise the possibility of previously unrealized subsets of T cells. We also revealed close linkage of TCRα/δ, IgH, and Igλ in Xenopus which, in combination with linkage analyses in other species, is consistent with the previous models for the emergence of these antigen receptor loci.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.