ArticleJournal of applied oral science : revista FOB
Analysis of the association between lactotransferrin (LTF) gene polymorphism and dental caries.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.Genes · 2026Pooled it
- The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis.BMC medical genetics · 2020Pooled it
- Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis.BMC oral health · 2020Pooled it
- The role of AMY1 gene copy number variation in dental caries susceptibility: insights from a Turkish population.BMC oral health · 2025Article
- Association Between Lactoferrin Gene Polymorphism and Dental Caries in Saudi Children: A Case-Control Study.Cureus · 2025Article
- Association Between Genetic Variants inInternational journal of dentistry · 2025Article
- Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and susceptibility to dental caries.Clinical oral investigations · 2024Article
- Exploring the Role of Lactoferrin in Managing Allergic Airway Diseases among Children: Unrevealing a Potential Breakthrough.Nutrients · 2024Review
- USP13 genetics and expression in a family with thyroid cancer.Endocrine · 2022Article
- Association of polymorphisms in genes involved in enamel formation, taste preference and immune response with early childhood caries in Saudi pre-school children.Saudi journal of biological sciences · 2021Article
- Genetic Aspects of Dental Erosive Wear and Dental Caries.International journal of dentistry · 2021Review
- Lack of associations between lactoferrin (The Journal of international medical research · 2020Article
- Cardiometabolic risk factors and lactoferrin: polymorphisms and plasma levels in French-Canadian children.Pediatric research · 2017Article
- Expression levels of JNK associated with polymorphic lactotransferrin haplotypes in human nasopharyngeal carcinoma.Oncology letters · 2016Article
- Familiar Papillary Thyroid Carcinoma in a Large Brazilian Family Is Not Associated with Succinate Dehydrogenase Defects.European thyroid journal · 2016Article
- Antimicrobial Functions of Lactoferrin Promote Genetic Conflicts in Ancient Primates and Modern Humans.PLoS genetics · 2016Article
- Polymorphisms in sweet taste genes (TAS1R2 and GLUT2), sweet liking, and dental caries prevalence in an adult Italian population.Genes & nutrition · 2015Article
- Lactoferrin: A Roadmap to the Borderland between Caries and Periodontal Disease.Journal of dental research · 2015Review
- Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups.Memorias do Instituto Oswaldo Cruz · 2015Article
- Gene polymorphism of β-defensin-1 is associated with susceptibility to periodontitis in Japanese.Odontology · 2015Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study evaluated the association between lactotransferrin (LTF) gene polymorphism (exon 2, A/G, Lys/Arg) and dental caries. MATERIAL AND
methodsA convenience sample of 110 individuals, 12 years old, was divided into: group 1, 48 individuals without caries experience (DMFT=0), and group 2, 62 subjects with caries experience (DMFT>or=1). DNA was obtained from a mouthwash with 3% glucose solution, followed by a scrapping of the oral mucosa. After DNA purification, polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) was performed to access the study polymorphism. The LTF A/G (Lys/Arg) polymorphism had been previously reported as located in exon 1.
resultsAllele 1 of the study polymorphism was associated with low DMFT index and showed a protective effect against caries experience (OR=0.16, IC=0.03-0.76, p=0.01).
conclusionsLactotransferrin A/G (exon 2, Lys/Arg) polymorphism was associated with susceptibility to dental caries in 12-year-old students.
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