ReviewChemical Society reviews2010
Current challenges of modeling diiron enzyme active sites for dioxygen activation by biomimetic synthetic complexes.
Review in Chemical Society reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
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- Unsymmetric bimetallic centres in metalloproteins and synthetic models.Nature reviews. Chemistry · 2026Review
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- Metal-α-Helix Peptide Frameworks.Journal of the American Chemical Society · 2025Article
- Controlling the Size of Molecular Copper Clusters Supported by a Multinucleating Macrocycle.Inorganic chemistry · 2024Article
- Redox Processes Involving Oxygen: The Surprising Influence of Redox-Inactive Lewis Acids.JACS Au · 2024Review
- 10Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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- Photocatalytic generation of a non-heme Fe(iii)-hydroperoxo species with OChemical science · 2022Article
- Bioinspired nonheme iron complex that triggers mitochondrial apoptotic signalling pathway specifically for colorectal cancer cells.Chemical science · 2022Article
- Heteroleptic Ligation by an endo-Functionalized Cage.Angewandte Chemie (International ed. in English) · 2021Article
- Structure-Spectroscopy Correlations for Intermediate Q of Soluble Methane Monooxygenase: Insights from QM/MM Calculations.Journal of the American Chemical Society · 2021Article
- Artificial Metalloproteins with Dinuclear Iron-Hydroxido Centers.Journal of the American Chemical Society · 2021Article
- Fate of model complexes with monocopper center towards the functional properties of type 2 and type 3 copper oxidases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021Article
- Opening the CoJournal of the American Chemical Society · 2020Article
- [BOAngewandte Chemie (International ed. in English) · 2020Article
- Proton-Electron Transfer to the Active Site Is Essential for the Reaction Mechanism of Soluble ΔJournal of the American Chemical Society · 2020Article
- A New Tetradentate Mixed Aza-Thioether Macrocycle and Its Complexation Behavior towards Fe(II), Ni(II) and Cu(II) Ions.Molecules (Basel, Switzerland) · 2020Article
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Abstract
This tutorial review describes recent progress in modeling the active sites of carboxylate-rich non-heme diiron enzymes that activate dioxygen to carry out several key reactions in Nature. The chemistry of soluble methane monooxygenase, which catalyzes the selective oxidation of methane to methanol, is of particular interest for (bio)technological applications. Novel synthetic diiron complexes that mimic structural, and, to a lesser extent, functional features of these diiron enzymes are discussed. The chemistry of the enzymes is also briefly summarized. A particular focus of this review is on models that mimic characteristics of the diiron systems that were previously not emphasized, including systems that contain (i) aqua ligands, (ii) different substrates tethered to the ligand framework, (iii) dendrimers attached to carboxylates to mimic the protein environment, (iv) two N-donors in a syn-orientation with respect to the iron-iron vector, and (v) a N-rich ligand environment capable of accessing oxygenated high-valent diiron intermediates.
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