ArticlePLoS genetics2010
Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed.
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- Amphioxus adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U and A-to-I deamination of DNA.Communications biology · 2023Article
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- Advanced maternal age has negative multigenerational impacts duringCurrent research in insect science · 2023Article
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- Characterization of Stress Responses in aBiomolecules · 2021Article
- Towards a unified framework to study causality in Earth-life systems.Molecular ecology · 2021Article
- Temperature dependence of spontaneous mutation rates.Genome research · 2021Article
- Balancing DNA repair to prevent ageing and cancer.Experimental cell research · 2021Review
- Review
- Stem Cell DNA Damage and Genome Mutation in the Context of Aging and Cancer Initiation.Cold Spring Harbor perspectives in biology · 2020Review
- Upregulated TNF/Eiger signaling mediates stem cell recovery and tissue homeostasis during nutrient resupply in Drosophila testis.Scientific reports · 2020Article
- Article
- Genomic instability and cancer: lessons fromOpen biology · 2020Review
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
- Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells.Environmental and molecular mutagenesis · 2018Review
- Sex Differences in Aging: Genomic Instability.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Review
- Genome instability: a conserved mechanism of ageing?Essays in biochemistry · 2017Review
- Ubiquitous overexpression of the DNA repair factorNPJ aging and mechanisms of disease · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Using a transgenic mouse model harboring a mutation reporter gene that can be efficiently recovered from genomic DNA, we previously demonstrated that mutations accumulate in aging mice in a tissue-specific manner. Applying a recently developed, similar reporter-based assay in Drosophila melanogaster, we now show that the mutation frequency at the lacZ locus in somatic tissue of flies is about three times as high as in mouse tissues, with a much higher fraction of large genome rearrangements. Similar to mice, somatic mutations in the fly also accumulate as a function of age, but they do so much more quickly at higher temperature, a condition which in invertebrates is associated with decreased life span. Most mutations were found to accumulate in the thorax and less in abdomen, suggesting the highly oxidative flight muscles as a possible source of genotoxic stress. These results show that somatic mutation loads in short-lived flies are much more severe than in the much longer-lived mice, with the mutation rate in flies proportional to biological rather than chronological aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.