ArticlePloS one2010
Semen may harbor HIV despite effective HAART: another piece in the puzzle.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Broad activation of latent HIV-1 in vivo.Nature communications · 2016Trial
- Emtricitabine seminal plasma and blood plasma population pharmacokinetics in HIV-infected men in the EVARIST ANRS-EP 49 study.Antimicrobial agents and chemotherapy · 2015Trial
- Testis Is a Sanctuary Site for HIV-1.Advances in experimental medicine and biology · 2025Review
- The importance of semen leukocytes in HIV-1 transmission and the development of prevention strategies.Human vaccines & immunotherapeutics · 2020Review
- Genital HIV-1 Shedding With Dolutegravir (DTG) Plus Lamivudine (3TC) Dual Therapy.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Experiences Using Pre-Exposure Prophylaxis for Safer Conception Among HIV Serodiscordant Heterosexual Couples in the United States.AIDS patient care and STDs · 2017Article
- Patterns of residual HIV-1 RNA shedding in the seminal plasma of patients on effective antiretroviral therapy.Basic and clinical andrology · 2017Article
- HIV-1 is undetectable in preejaculatory secretions from HIV-1-infected men on suppressive HAART.AIDS (London, England) · 2016Article
- Seminal HIV-1 RNA Detection in Heterosexual African Men Initiating Antiretroviral Therapy.The Journal of infectious diseases · 2016Article
- Tissue reservoirs of HIV.Current opinion in HIV and AIDS · 2016Review
- Detection of Simian Immunodeficiency Virus in Semen, Urethra, and Male Reproductive Organs during Efficient Highly Active Antiretroviral Therapy.Journal of virology · 2015Article
- Significance and clinical management of persistent low-level viremia and very-low-level viremia in HIV-1-infected patients.Antimicrobial agents and chemotherapy · 2014Article
- Understanding HIV compartments and reservoirs.Current HIV/AIDS reports · 2014Review
- A combination microbicide gel protects macaques against vaginal simian human immunodeficiency virus-reverse transcriptase infection, but only partially reduces herpes simplex virus-2 infection after a single high-dose cochallenge.AIDS research and human retroviruses · 2014Article
- Article
- Shedding of HIV and human herpesviruses in the semen of effectively treated HIV-1-infected men who have sex with men.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Recent developments in human immunodeficiency virus-1 latency research.The Journal of general virology · 2013Review
- Overcoming pharmacologic sanctuaries.Current opinion in HIV and AIDS · 2013Review
- Suppressed but still infectious.Future virology · 2013Article
- Highly active antiretroviral therapy does not completely suppress HIV in semen of sexually active HIV-infected men who have sex with men.AIDS (London, England) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe risk of male-to-female intravaginal HIV-1 transmission is estimated at about 1 event per 200-2000 coital acts. The aim of this study was to assess the residual risk of HIV presence in semen in patients under HAART therapy. METHODS AND
findingsThe study took place in France from October 2001 to March 2009. 394 paired blood and semen samples were provided from 332 HIV-1 infected men. The Roche Cobas AMPLICOR Monitor HIV assay was used to quantify HIV-1 RNA in blood and in seminal plasma. Three percent of 394 HIV-1 infected men enrolled in an assisted reproductive technology program harbored detectable HIV-1 RNA in semen, although they had no other sexually transmitted disease and their blood viral load was undetectable for at least 6 months under antiretroviral treatment.
conclusionThese data suggest that undetectable plasma HIV RNA means a lower risk of viral transmission through seminal fluid on a population level, but not necessarily at the level of the individual.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.