ArticlePLoS pathogens2010
Alternative sigma factor sigmaH modulates prophage integration and excision in Staphylococcus aureus.
Article in PLoS pathogens, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Experimental evolution under different nutritional conditions changes the genomic architecture and virulence of Acinetobacter baumannii.Communications biology · 2024Article
- Regulatory Role of Anti-Sigma Factor RsbW in Clostridioides difficile Stress Response, Persistence, and Infection.Journal of bacteriology · 2023Article
- RecT Affects Prophage Lifestyle and Host Core Cellular Processes in Pseudomonas aeruginosa.Applied and environmental microbiology · 2022Article
- Natural transformation allows transfer of SCCmec-mediated methicillin resistance in Staphylococcus aureus biofilms.Nature communications · 2022Article
- The induction of natural competence adapts staphylococcal metabolism to infection.Nature communications · 2022Article
- The gene regulatory network ofFrontiers in microbiology · 2022Article
- Diversity of bacteriophages encoding Panton-Valentine leukocidin in temporally and geographically related Staphylococcus aureus.PloS one · 2020Article
- Regulation ofMicrobiology spectrum · 2019Review
- Bacterial 'Grounded' Prophages: Hotspots for Genetic Renovation and Innovation.Frontiers in genetics · 2019Article
- A Linear Plasmid-Like Prophage of Actinomyces odontolyticus Promotes Biofilm Assembly.Applied and environmental microbiology · 2018Article
- Identification of a unique transcriptional architecture for the sigS operon in Staphylococcus aureus.FEMS microbiology letters · 2018Article
- Physiological Function of Rac Prophage During Biofilm Formation and Regulation of Rac Excision in Escherichia coli K-12.Scientific reports · 2015Article
- Modulation of ccrAB Expression and SCCmec Excision by an Inverted Repeat Element and SarS in Methicillin-Resistant Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2015Article
- The membrane protein PrsS mimics σS in protecting Staphylococcus aureus against cell wall-targeting antibiotics and DNA-damaging agents.Microbiology (Reading, England) · 2015Article
- Phage-mediated horizontal transfer of a Staphylococcus aureus virulence-associated genomic island.Scientific reports · 2015Article
- Article
- Transcription termination controls prophage maintenance in Escherichia coli genomes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The extracytoplasmic function sigma factor σS protects against both intracellular and extracytoplasmic stresses in Staphylococcus aureus.Journal of bacteriology · 2012Article
- Alternative sigma factor σH activates competence gene expression in Lactobacillus sakei.BMC microbiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prophage is one of the most important components of variable regions in bacterial genomes. Some prophages carry additional genes that may enhance the toxicity and survival ability of their host bacteria. This phenomenon is predominant in Staphylococcus aureus, a very common human pathogen. Bioinformatics analysis of several staphylococcal prophages revealed a highly conserved 40-bp untranslated region upstream of the int gene. A small transcript encoding phage integrase was identified to be initiated from the region, demonstrating that the untranslated region contained a promoter for int. No typical recognition sequence for either sigma(A) or sigma(B) was identified in the 40-bp region. Experiments both in vitro and in vivo demonstrated that sigma(H) recognized the promoter and directed transcription. Genetic deletion of sigH altered the int expression, and subsequently, the excision proportion of prophage DNAs. Phage assays further showed that sigH affected the ability of spontaneous lysis and lysogenization in S. aureus, suggesting that sigH plays a role in stabilizing the lysogenic state. These findings revealed a novel mechanism of prophage integration specifically regulated by a host-source alternative sigma factor. This mechanism suggests a co-evolution strategy of staphylococcal prophages and their host bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.