ArticleFrontiers in behavioral neuroscience2010
New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
Article in Frontiers in behavioral neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: A meta-analysis.Medicine · 2019Pooled it
- Replication of ZNF804A gene variant associations with risk of heroin addiction.Genes, brain, and behavior · 2015Pooled it
- BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies.PloS one · 2013Pooled it
- PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.Journal of molecular neuroscience : MN · 2012Pooled it
- Defective neurogenesis and schizophrenia-like behavior in PARP-1-deficient mice.Cell death & disease · 2019Article
- Purinergic signaling and energy homeostasis in psychiatric disorders.Current molecular medicine · 2015Review
- Article
- Schizophrenia shows a unique metabolomics signature in plasma.Translational psychiatry · 2012Article
- Is lead exposure in early life an environmental risk factor for Schizophrenia? Neurobiological connections and testable hypotheses.Neurotoxicology · 2012Review
- Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a highly heritable disorder, but the identification of specific genes has proven to be a difficult endeavor. Genes involved in the dopaminergic system are considered to be major candidates since the "dopamine hypothesis" of impairment in dopaminergic neurotransmission is one of the most widely accepted hypotheses of the etiology of schizophrenia. The overall findings from candidate studies do provide some support for the "dopamine hypothesis." However, results from the first systematic genome-wide association (GWA) studies have implicated variants within ZNF804A, NRGN, TCF4, and variants in the MHC region on chromosome 6p22.1. Although these genes may not immediately impact on dopaminergic neurotransmission, it remains possible that downstream impairments in dopaminergic function are caused. Furthermore, only a very small fraction of all truly associated genetic variants have been detected and many more associated variants will be identified in the future by GWA studies and alternative approaches. The results of these studies may allow a more comprehensive re-evaluation of the dopamine hypothesis.
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Registered trials
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