ArticleFrontiers in neuroengineering2010
Experimental Investigation on Spontaneously Active Hippocampal Cultures Recorded by Means of High-Density MEAs: Analysis of the Spatial Resolution Effects.
Article in Frontiers in neuroengineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Seize the Data: A User-Friendly GUI for High-Resolution Analysis of Seizure Dynamics in HD-MEA Recordings.eNeuro · 2026Article
- Microscale dysfunction and mesoscale compensation in degenerating neuronal networks.Network neuroscience (Cambridge, Mass.) · 2026Article
- Inferring structure of cortical neuronal networks from activity data: A statistical physics approach.PNAS nexus · 2025Article
- Identifying Effective Connectivity between Stochastic Neurons with Variable-Length Memory Using a Transfer Entropy Rate Estimator.Brain sciences · 2024Article
- Large-Area Field Potential Imaging Having Single Neuron Resolution Using 236 880 Electrodes CMOS-MEA Technology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- [Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Article
- Unique Features of Network Bursts Emerge From the Complex Interplay of Excitatory and Inhibitory Receptors in Rat Neocortical Networks.Frontiers in cellular neuroscience · 2019Article
- Identification of excitatory-inhibitory links and network topology in large-scale neuronal assemblies from multi-electrode recordings.PLoS computational biology · 2018Article
- Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks.PLoS computational biology · 2017Article
- High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies.Scientific reports · 2017Article
- Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays.Frontiers in neuroscience · 2016Article
- Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks.Frontiers in neural circuits · 2016Article
- An in vitro method to manipulate the direction and functional strength between neural populations.Frontiers in neural circuits · 2015Review
- Cingulate seizure-like activity reveals neuronal avalanche regulated by network excitability and thalamic inputs.BMC neuroscience · 2014Article
- Functional connectivity estimation over large networks at cellular resolution based on electrophysiological recordings and structural prior.Frontiers in neuroanatomy · 2014Article
- Multi-electrode array technologies for neuroscience and cardiology.Nature nanotechnology · 2013Review
- Article
- Extending transfer entropy improves identification of effective connectivity in a spiking cortical network model.PloS one · 2011Article
- Formation of Essential Ultrastructural Interface between Cultured Hippocampal Cells and Gold Mushroom-Shaped MEA- Toward "IN-CELL" Recordings from Vertebrate Neurons.Frontiers in neuroengineering · 2011Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on experiments performed with high-resolution Active Pixel Sensor microelectrode arrays (APS-MEAs) coupled with spontaneously active hippocampal cultures, this work investigates the spatial resolution effects of the neuroelectronic interface on the analysis of the recorded electrophysiological signals. The adopted methodology consists, first, in recording the spontaneous activity at the highest spatial resolution (interelectrode separation of 21 mum) from the whole array of 4096 microelectrodes. Then, the full resolution dataset is spatially downsampled in order to evaluate the effects on raster plot representation, array-wide spike rate (AWSR), mean firing rate (MFR) and mean bursting rate (MBR). Furthermore, the effects of the array-to-network relative position are evaluated by shifting a subset of equally spaced electrodes on the entire recorded area. Results highlight that MFR and MBR are particularly influenced by the spatial resolution provided by the neuroelectronic interface. On high-resolution large MEAs, such analysis better represent the time-based parameterization of the network dynamics. Finally, this work suggest interesting capabilities of high-resolution MEAs for spatial-based analysis in dense and low-dense neuronal preparation for investigating signaling at both local and global neuronal circuitries.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.