Evidence map›Paper›PMID 20485288›Full record

SynthesisBritish journal of cancer2010

Alcohol intake and endometrial cancer risk: a meta-analysis of prospective studies.

E Friberg, N Orsini, C S Mantzoros, A Wolk

Open access · hybridAbstract readMeta-Analysis
In one paragraph

Synthesis in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Risk assessment for endometrial cancer in women with abnormal vaginal bleeding: Results from the prospective IETA-1 cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022
    Observational
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

E FribergDivision of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. emilie.friberg@ki.se
N Orsini
C S Mantzoros
A Wolk
Karolinska Institutet · SEBeth Israel Deaconess Medical Center · US

Funding

BIOCHEMICAL AND GENETIC MARKERS OF TYPE 2 DIABETES RISKR01DK058845 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, FRANK B · 2001 to 2013
$7.8M
Role of Leptin in the Neuroendocrine Response to FastingR01DK058785 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MANTZOROS, CHRISTOS S · 2001 to 2011
$4.0M
The Role of Leptin in the Maintenance of a Reduced Body WeightR01DK079929 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MANTZOROS, CHRISTOS S · 2008 to 2012
$1.8M
Leptin and Adipokine PhysiologyK24DK081913 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MANTZOROS, CHRISTOS S · 2008 to 2020
$1.5M
Role of Leptin in the Neuroendocrine Response to FastingR56DK058785 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MANTZOROS, CHRISTOS S · 2005 to 2005
$85k
NIDDK NIH HHS DK 081913NIDDK NIH HHS DK58785NIDDK NIH HHS DK58845NIDDK NIH HHS DK79929NIDDK NIH HHS K24 DK081913NIDDK NIH HHS R01 DK058785NIDDK NIH HHS R01 DK058845NIDDK NIH HHS R01 DK079929NIDDK NIH HHS R56 DK058785
6 · The paper itself

Abstract

backgroundStudies on alcohol intake in relation to endometrial cancer risk have produced inconsistent results.

methodsFor a meta-analysis, we identified cohort studies of alcohol and endometrial cancer by a literature search of Pub-Med and Embase up to 1 March 2010 and by searching the reference lists of relevant articles.

resultsSeven cohort studies, including 1,511,661 participants and 6086 endometrial cancer cases, were included in the dose-response random-effect meta-regression model. Compared with non-drinkers, women drinking less than 1 drink of alcohol (13 g of ethanol) per day had a lower risk for endometrial cancer; this risk was lower by 4% (95% confidence interval (95% CI): 0.93-1.00) for consumption up to 0.5 drink per day and by 7% (95% CI: 0.85-1.02) for consumption up to 1 drink. However, we found evidence of an increased risk for endometrial cancer for intakes higher than two alcoholic drinks per day: compared with non-drinkers, the risk was higher by 14% (95% CI: 0.95-1.36) for 2-2.5 drinks per day and by 25% (95% CI: 0.98-1.58) for >2.5 drinks per day.

conclusionOur meta-analysis indicates a possible J-shaped relationship between alcohol intake and endometrial cancer risk.

Indexed as

Alcohol DrinkingCohort StudiesEndometrial NeoplasmsFemaleHumansProspective StudiesRisk Factors

Identifiers

PMID20485288
PMCPMC2905297
OpenAlexW1978571214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.