ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Theta-band phase locking of orbitofrontal neurons during reward expectancy.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Intensity-dependent tACS entrainment effects in a cortical microcircuit: a computational study.Scientific reports · 2026Article
- Reward contingency reorganizes lateral orbitofrontal cortex pyramidal neuron activity from reward-aligned to action-aligned during associative learning.Frontiers in cellular neuroscience · 2026Article
- Repeated alcohol drinking in mice is associated with bidirectional alterations in corticostriatal coherence.Neuropharmacology · 2025Article
- Uncertainty, Cognitive Control and Theta-Band Activity: A Relationship That Depends on Metacontrol Requirements.Human brain mapping · 2025Article
- Disruption of hippocampal-prefrontal neural dynamics and risky decision-making in a mouse model of Alzheimer's disease.Cell reports · 2025Article
- Serotonin transporter knockout in rats reduces beta- and gamma-band functional connectivity between the orbitofrontal cortex and amygdala during auditory discrimination.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Adolescents rats engage the orbitofrontal-striatal pathway differently than adults during impulsive actions.Scientific reports · 2024Article
- Causal functional maps of brain rhythms in working memory.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Offline orbitofrontal cortex reactivation depends on recency of place-reward changes and coheres with hippocampal replay.iScience · 2024Article
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- Beta and theta oscillations track effort and previous reward in human basal ganglia and prefrontal cortex during decision making.bioRxiv : the preprint server for biology · 2023Article
- Activation of Kv7 channels normalizes hyperactivity of the VTA-NAcLat circuit and attenuates methamphetamine-induced conditioned place preference and sensitization in mice.Molecular psychiatry · 2023Article
- Paving the Way for Memory Enhancement: Development and Examination of a Neurofeedback System Targeting the Medial Temporal Lobe.Biomedicines · 2023Article
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- Prefrontal network engagement by deep brain stimulation in limbic hubs.Frontiers in human neuroscience · 2023Article
- Theta oscillations in anterior cingulate cortex and orbitofrontal cortex differentially modulate accuracy and speed in flexible reward learning.Oxford open neuroscience · 2023Article
- Functional control of oscillator networks.Nature communications · 2022Article
- Hippocampal signals modify orbitofrontal representations to learn new paths.Current biology : CB · 2022Article
2 more citing papers are in PubMed but not listed here.
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The expectancy of a rewarding outcome following actions and cues is coded by a network of brain structures including the orbitofrontal cortex. Thus far, predicted reward was considered to be coded by time-averaged spike rates of neurons. However, besides firing rate, the precise timing of action potentials in relation to ongoing oscillations in local field potentials is thought to be of importance for effective communication between brain areas. We performed multineuron and field potential recordings in orbitofrontal cortex of rats performing olfactory discrimination learning to study the temporal structure of coding predictive of outcome. After associative learning, field potentials were marked by theta oscillations, both in advance and during delivery of reward. Orbitofrontal neurons, especially those coding information about upcoming reward with their firing rate, phase locked to these oscillations in anticipation of reward. When established associations were reversed, phase locking collapsed in the anticipatory task phase, but returned when reward became predictable again after relearning. Behaviorally, the outcome anticipation phase was marked by licking responses, but the frequency of lick responses was dissociated from the strength of theta-band phase locking. The strength of theta-band phase locking by orbitofrontal neurons robustly follows the dynamics of associative learning as measured by behavior and correlates with the rat's current outcome expectancy. Theta-band phase locking may facilitate communication of outcome-related information between reward-related brain areas and offers a novel mechanism for coding value signals during reinforcement learning.
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