ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Heterogeneity in ventricular zone neural precursors contributes to neuronal fate diversity in the postnatal neocortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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Who cites it
101 citing papers in PubMed.
- Early fate diversification of radial glial progenitors during corticogenesis.Science advances · 2026Article
- FlashTag-mediated Labeling for Intraventricular Macrophages in the Embryonic Brain.Bio-protocol · 2025Article
- Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain.Cell reports · 2024Article
- Review
- MKL/SRF and Bcl6 mutual transcriptional repression safeguards the fate and positioning of neocortical progenitor cells mediated by RhoA.Science advances · 2023Article
- Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis.Cell death & disease · 2023Article
- The anatomy of neuroepithelial tumours.Brain : a journal of neurology · 2023Article
- Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis.The EMBO journal · 2022Article
- Breasi-CRISPR: an efficient genome-editing method to interrogate protein localization and protein-protein interactions in the embryonic mouse cortex.Development (Cambridge, England) · 2022Article
- Preconfigured dynamics in the hippocampus are guided by embryonic birthdate and rate of neurogenesis.Nature neuroscience · 2022Article
- Coordinating cerebral cortical construction and connectivity: Unifying influence of radial progenitors.Neuron · 2022Review
- Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.Nature communications · 2022Article
- Development of prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes.Neuroscience bulletin · 2022Article
- From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Molecular evolutionary analysis of human primary microcephaly genes.BMC ecology and evolution · 2021Article
- Diversity in striatal synaptic circuits arises from distinct embryonic progenitor pools in the ventral telencephalon.Cell reports · 2021Article
- Behavior and lineage progression of neural progenitors in the mammalian cortex.Current opinion in neurobiology · 2021Review
- Length of the Neurogenic Period-A Key Determinant for the Generation of Upper-Layer Neurons During Neocortex Development and Evolution.Frontiers in cell and developmental biology · 2021Review
- Integrin β3 organizes dendritic complexity of cerebral cortical pyramidal neurons along a tangential gradient.Molecular brain · 2020Article
41 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
The recent discovery of short neural precursors (SNPs) in the murine neocortical ventricular zone (VZ) challenges the widely held view that radial glial cells (RGCs) are the sole occupants of this germinal compartment and suggests that precursor variety is an important factor of brain development. Here, we use in utero electroporation and genetic fate mapping to show that SNPs and RGCs cohabit the VZ but display different cell cycle kinetics and generate phenotypically different progeny. In addition, we find that RGC progeny undergo additional rounds of cell division as intermediate progenitor cells (IPCs), whereas SNP progeny generally produce postmitotic neurons directly from the VZ. By clearly defining SNPs as bona fide VZ residents, separate from both RGCs and IPCs, and uncovering their unique proliferative and lineage properties, these results demonstrate how individual neural precursor groups in the embryonic rodent VZ create diversity in the overlying neocortex.
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