Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- The social evaluation of faces: a meta-analysis of functional neuroimaging studies.Social cognitive and affective neuroscience · 2013Pooled it
- The effect of intranasal oxytocin on the neuropsychological substrates of intergroup categorization.Brain imaging and behavior · 2026Trial
- Oxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame.Molecular psychiatry · 2024Trial
- Vasopressin enhances human preemptive strike in both males and females.Scientific reports · 2019Trial
- A Single Dose, Randomized, Controlled Proof-Of-Mechanism Study of a Novel Vasopressin 1a Receptor Antagonist (RG7713) in High-Functioning Adults with Autism Spectrum Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Neuroticism modulates the effects of intranasal vasopressin treatment on the neural response to positive and negative social interactions.Neuropsychologia · 2015Trial
- Intranasal administration of oxytocin increases compassion toward women.Social cognitive and affective neuroscience · 2015Trial
- Oxytocin and vasopressin modulate risk-taking.Physiology & behavior · 2015Trial
- Posttraumatic stress disorder and partner-specific social cognition: a pilot study of sex differences in the impact of arginine vasopressin.Biological psychology · 2013Trial
- The neural circuitry of reward processing in complex social comparison: evidence from an event-related FMRI study.PloS one · 2013Trial
- Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.Journal of neural transmission (Vienna, Austria : 1996) · 2012Trial
- Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men.Psychoneuroendocrinology · 2012Trial
- Trial
- Vasopressin modulates social recognition-related activity in the left temporoparietal junction in humans.Translational psychiatry · 2011Trial
- Vasopressin 1a Receptor Antagonists for Pathological Aggression in Neurodegenerative and Other CNS Diseases.Biomedicines · 2026Review
- Hypothalamic subunit volumes and relations to violence and psychopathy in male offenders with or without a psychotic disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Plasma copeptin is coupled to resting-state frontoinsular-subgenual alpha dynamics in major depression with comorbid post-traumatic stress disorder.Frontiers in endocrinology · 2026Article
- A pharmacological and brain imaging study of human vasopressin AVP1BR receptor functional polymorphisms.BMC neuroscience · 2025Article
- Stress enhances aggression in male rats with genetic stress hyper-reactivity.Genes, brain, and behavior · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
The neuropeptide vasopressin is a modulator of mammalian social behavior and emotion, particularly fear, aggression, and anxiety. In humans, the neural circuitry underlying behavioral effects of vasopressin is unknown. Using a double-blind crossover administration of 40 IU of vasopressin or placebo and functional MRI during processing of facial emotions in healthy male volunteers, we show that vasopressin specifically reduces differential activation in the subgenual cingulate cortex. Structural equation modeling of a previously evaluated circuit between amygdala, subgenual cingulate, and supragenual cingulate revealed altered effective connectivity between subgenual and supragenual cingulate under vasopressin. Our data demonstrate an impact of vasopressin on activity and connectivity in the cortical component of a medial prefrontal cortex-amygdala circuit implicated in emotional regulation, providing the first data on the neural basis for the effects of vasopressin on social behavior in humans with potential therapeutic significance for mood and anxiety disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.