ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Rac1 regulates neuronal polarization through the WAVE complex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed, 182 citations in OpenAlex.
- Article
- Review
- Article
- Rac1 and Nectin3 are essential for planar cell polarity-directed axon guidance in the peripheral auditory system.Development (Cambridge, England) · 2025Article
- Spatial and planar profiling of Rac1/Cdc42 signaling in Alzheimer's disease brain.Journal of Alzheimer's disease : JAD · 2024Article
- Neuronal maturation and axon regeneration: unfixing circuitry to enable repair.Nature reviews. Neuroscience · 2024Review
- Article
- Advances in Understanding the Molecular Mechanisms of Neuronal Polarity.Molecular neurobiology · 2023Review
- TORC1 regulation of dendrite regrowth after pruning is linked to actin and exocytosis.PLoS genetics · 2023Article
- Article
- Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology.Brain : a journal of neurology · 2022Article
- Mechanisms of Axon Growth and Regeneration: Moving between Development and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Local changes in microtubule network mobility instruct neuronal polarization and axon specification.Science advances · 2022Article
- Rac-deficient cerebellar granule neurons die before they migrate to the internal granule layer.Scientific reports · 2022Article
- The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization.Life science alliance · 2022Article
- Lamellipodia-like actin networks in cells lacking WAVE regulatory complex.Journal of cell science · 2022Article
- Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation.Nature communications · 2022Article
- Loss of ARHGAP15 affects the directional control of migrating interneurons in the embryonic cortex and increases susceptibility to epilepsy.Frontiers in cell and developmental biology · 2022Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 4 countries.
Funding
Abstract
Neuronal migration and axon growth, key events during neuronal development, require distinct changes in the cytoskeleton. Although many molecular regulators of polarity have been identified and characterized, relatively little is known about their physiological role in this process. To study the physiological function of Rac1 in neuronal development, we have generated a conditional knock-out mouse, in which Rac1 is ablated in the whole brain. Rac1-deficient cerebellar granule neurons, which do not express other Rac isoforms, showed impaired neuronal migration and axon formation both in vivo and in vitro. In addition, Rac1 ablation disrupts lamellipodia formation in growth cones. The analysis of Rac1 effectors revealed the absence of the Wiskott-Aldrich syndrome protein (WASP) family verprolin-homologous protein (WAVE) complex from the plasma membrane of knock-out growth cones. Loss of WAVE function inhibited axon growth, whereas overexpression of a membrane-tethered WAVE mutant partially rescued axon growth in Rac1-knock-out neurons. In addition, pharmacological inhibition of the WAVE complex effector Arp2/3 also reduced axon growth. We propose that Rac1 recruits the WAVE complex to the plasma membrane to enable actin remodeling necessary for axon growth.
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