ArticleInvestigative ophthalmology & visual science2010
Genetic deletion of the adenosine A2A receptor confers postnatal development of relative myopia in mice.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 45 citations in OpenAlex.
- Impaired P4HA1-Driven Hydroxyproline Formation Mediates Scleral Collagen Disruption in Form-Deprivation Myopia.Investigative ophthalmology & visual science · 2026Article
- Inhibition of Retinal AdoRA2a Activity Attenuates Myopia Progression.Investigative ophthalmology & visual science · 2026Article
- Decreased scleral Wnt5aNature communications · 2025Article
- Childhood Myopia Part II: Treatment Mechanisms, Emerging Options, and Considerations.Investigative ophthalmology & visual science · 2025Review
- Critical role of lipid metabolism in axial myopia development.International journal of ophthalmology · 2025Review
- Insights into Myopia from Mouse Models.Annual review of vision science · 2024Review
- Role of 7-methylxanthine in myopia prevention and control: a mini-review.International journal of ophthalmology · 2023Review
- Candidate pathways for retina to scleral signaling in refractive eye growth.Experimental eye research · 2022Review
- Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated.Investigative ophthalmology & visual science · 2021Article
- Topically instilled caffeine selectively alters emmetropizing responses in infant rhesus monkeys.Experimental eye research · 2021Article
- Intravitreal injection of adenosine AScientific reports · 2019Article
- IMI - Report on Experimental Models of Emmetropization and Myopia.Investigative ophthalmology & visual science · 2019Review
- Article
- Adenosine receptor distribution in Rhesus monkey ocular tissue.Experimental eye research · 2018Article
- Scleral hypoxia is a target for myopia control.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Effect of green flickering light on myopia development and expression of M1 muscarinic acetylcholine receptor in guinea pigs.International journal of ophthalmology · 2018Article
- The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques.Investigative ophthalmology & visual science · 2018Article
- Association of Body Length with Ocular Parameters in Mice.Optometry and vision science : official publication of the American Academy of Optometry · 2017Article
- Genome-Wide Scleral Micro- and Messenger-RNA Regulation During Myopia Development in the Mouse.Investigative ophthalmology & visual science · 2016Article
- Altered Refractive Development in Mice With Reduced Levels of Retinal Dopamine.Investigative ophthalmology & visual science · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
purposeTo critically evaluate whether the adenosine A2A receptor (A2AR) plays a role in postnatal refractive development in mice.
methodsCustom-built biometric systems specifically designed for mice were used to assess the development of relative myopia by examining refraction and biometrics in A2AR knockout (KO) mice and wild-type (WT) littermates between postnatal days (P)28 and P56. Ocular dimensions were measured by customized optical coherence tomography (OCT), refractive state by eccentric infrared photorefraction (EIR), and corneal radius of curvature by modified keratometry. Scleral collagen diameter and density were examined by electron microscopy on P35. The effect of A2AR activation on collagen mRNA expression and on soluble collagen production was examined in cultured human scleral fibroblasts by real-time RT-PCR and a collagen assay kit.
resultsCompared with WT littermates, the A2AR KO mice displayed relative myopia (average difference, 5.1 D between P28 and P35) and associated increases in VC depth and axial length from P28 to P56. Furthermore, the myopic shift in A2AR KO mice was associated with ultrastructural changes in the sclera: Electron microscopy revealed denser collagen fibrils with reduced diameter in A2AR KO compared with WT. Last, A2AR activation induced expression of mRNAs for collagens I, III, and V and increased production of soluble collagen in cultured human scleral fibroblasts.
conclusionsGenetic deletion of the A2AR promotes development of relative myopia with increased axial length and altered scleral collagen fiber structure during postnatal development in mice. Thus, the A2AR may be important in normal refractive development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.