ArticleMolecular biology of the cell2010
Cdo interacts with APPL1 and activates Akt in myoblast differentiation.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Review
- MicroRNA-668-3p inhibits myoblast proliferation and differentiation by targeting Appl1.BMC genomics · 2023Article
- Article
- Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress.Journal of ginseng research · 2022Article
- Ginsenoside Rg3 protects glucocorticoid‑induced muscle atrophyMolecular medicine reports · 2022Article
- BST204 Protects Dexamethasone-Induced Myotube Atrophy through the Upregulation of Myotube Formation and Mitochondrial Function.International journal of environmental research and public health · 2021Article
- Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism.Frontiers in nutrition · 2021Article
- Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Journal of cachexia, sarcopenia and muscle · 2020Article
- Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling-mediated muscular hypertrophy and myoblast differentiation.Journal of ginseng research · 2020Article
- Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy.Scientific reports · 2019Article
- Ginsenoside Rg1 augments oxidative metabolism and anabolic response of skeletal muscle in mice.Journal of ginseng research · 2019Article
- Black ginseng activates Akt signaling, thereby enhancing myoblast differentiation and myotube growth.Journal of ginseng research · 2018Article
- Canadine from Corydalis turtschaninovii Stimulates Myoblast Differentiation and Protects against Myotube Atrophy.International journal of molecular sciences · 2017Article
- MicroRNA-135a is involved in podocyte injury in a transient receptor potential channel 1-dependent manner.International journal of molecular medicine · 2017Article
- Ginsenoside Rg1 fromJournal of ginseng research · 2017Article
- APPL1 is a multifunctional endosomal signaling adaptor protein.Biochemical Society transactions · 2017Review
- Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts.PloS one · 2017Article
- PKN2 and Cdo interact to activate AKT and promote myoblast differentiation.Cell death & disease · 2016Article
- Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-cell interactions between muscle precursors are required for myogenic differentiation; however, underlying mechanisms are largely unknown. Promyogenic cell surface protein Cdo functions as a component of multiprotein complexes containing other cell adhesion molecules, Boc, Neogenin and N-cadherin, and mediates some of signals triggered by cell-cell interactions between muscle precursors. Cdo activates p38MAPK via interaction with two scaffold proteins JLP and Bnip-2 to promote myogenesis. p38MAPK and Akt signaling are required for myogenic differentiation and activation of both signaling pathways is crucial for efficient myogenic differentiation. We report here that APPL1, an interacting partner of Akt, forms complexes with Cdo and Boc in differentiating myoblasts. Both Cdo and APPL1 are required for efficient Akt activation during myoblast differentiation. The defective differentiation of Cdo-depleted cells is fully rescued by overexpression of a constitutively active form of Akt, whereas overexpression of APPL1 fails to do so. Taken together, Cdo activates Akt through association with APPL1 during myoblast differentiation, and this complex likely mediates some of the promyogenic effect of cell-cell interaction. The promyogenic function of Cdo involves a coordinated activation of p38MAPK and Akt via association with scaffold proteins, JLP and Bnip-2 for p38MAPK and APPL1 for Akt.
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