ArticleCirculation. Cardiovascular imaging2010
Incremental diagnostic value of regional left ventricular function over coronary assessment by cardiac computed tomography for the detection of acute coronary syndrome in patients with acute chest pain: from the ROMICAT trial.
Article in Circulation. Cardiovascular imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Clinical indications for cardiac computed tomography. From the Working Group of the Cardiac Radiology Section of the Italian Society of Medical Radiology (SIRM).La Radiologia medica · 2012Guideline
- Korean guidelines for the appropriate use of cardiac CT.Korean journal of radiologyGuideline
- Trial
- Prognostic value of CT angiography for major adverse cardiac events in patients with acute chest pain from the emergency department: 2-year outcomes of the ROMICAT trial.JACC. Cardiovascular imaging · 2011Trial
- [The Potential Role of Cardiac CT in Patients with Acute Coronary Syndrome].Taehan Yongsang Uihakhoe chi · 2022Review
- Current Role of Computed Tomography in the Evaluation of Acute Coronary Syndrome.Diagnostics (Basel, Switzerland) · 2021Review
- Functional cardiac CT-Going beyond Anatomical Evaluation of Coronary Artery Disease with Cine CT, CT-FFR, CT Perfusion and Machine Learning.The British journal of radiology · 2020Review
- Automated 4-dimensional regional myocardial strain evaluation using cardiac computed tomography.The international journal of cardiovascular imaging · 2020Article
- Cardiac Computed Tomography - More Than Coronary Arteries? A Clinical Update.RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 2019Review
- Precision of regional wall motion estimates from ultra-low-dose cardiac CT using SQUEEZ.The international journal of cardiovascular imaging · 2018Article
- Advances in cardiac CT contrast injection and acquisition protocols.Cardiovascular diagnosis and therapy · 2017Article
- Left-sided cardiac chamber evaluation using single-phase mid-diastolic coronary computed tomography angiography: derivation of normal values and comparison with conventional end-diastolic and end-systolic phases.European radiology · 2016Article
- Highly sensitive troponin and coronary computed tomography angiography in the evaluation of suspected acute coronary syndrome in the emergency department.European heart journal · 2016Review
- Correlation of CT-based regional cardiac function (SQUEEZ) with myocardial strain calculated from tagged MRI: an experimental study.The international journal of cardiovascular imaging · 2016Article
- Quantitative Assessment of Left Ventricular Function and Myocardial Mass: A Comparison of Coronary CT Angiography with Cardiac MRI and Echocardiography.Polish journal of radiology · 2016Article
- Dose levels and image quality of second-generation 128-slice dual-source coronary CT angiography in clinical routine.La Radiologia medica · 2015Article
- Performance of Automated Software in the Assessment of Segmental Left Ventricular Function in Cardiac CT: Comparison with Cardiac Magnetic Resonance.European radiology · 2015Article
- Quantitative assessment of right ventricular function and pulmonary regurgitation in surgically repaired tetralogy of Fallot using 256-slice CT: comparison with 3-Tesla MRI.European radiology · 2014Article
- Feasibility of a radiation dose conserving CT protocol for myocardial function assessment.The British journal of radiology · 2014Article
- Imaging techniques for the assessment of suspected acute coronary syndromes in the emergency department.Current problems in cardiology · 2014Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe incremental value of regional left ventricular function (LVF) over coronary assessment to detect acute coronary syndrome (ACS) is uncertain. METHODS AND
resultsWe analyzed 356 patients (mean age, 53+/-12 years; 62% men) with acute chest pain and inconclusive initial emergency department evaluation. Patients underwent 64-slice contrast-enhanced cardiac computed tomography before hospital admission. Caregivers and patients remained blinded to the results. Regional LVF and presence of coronary atherosclerotic plaque and significant stenosis (>50%) were separately assessed by 2 independent readers. Incremental value of regional LVF to predict ACS was determined in the entire cohort and in subgroups of patients with nonobstructive coronary artery disease, inconclusive assessment for stenosis (defined as inability to exclude significant stenosis due to calcium or motion), and significant stenosis. During their index hospitalization, 31 patients were ultimately diagnosed with ACS (8 myocardial infarction, 22 unstable angina), of which 74% (23 patients) had regional LV dysfunction. Adding regional LVF resulted in a 10% increase in sensitivity to detect ACS by cardiac computed tomography (87%; 95% confidence interval, 70% to 96%) and significantly improved the overall accuracy (c-statistic: 0.88 versus 0.94 and 0.79 versus 0.88, for extent of plaque and presence of stenosis, respectively; both P<0.03). The diagnostic accuracy of regional LVF for detection of ACS has 89% sensitivity and 86% specificity in patients with significant stenosis (n=33) and 60% sensitivity and 86% specificity in patients with inconclusive coronary computed tomographic angiography (n=33).
conclusionsRegional LVF assessment at rest improves diagnostic accuracy for ACS in patients with acute chest pain, especially in those with coronary artery disease and thus may be helpful to guide further management in patients at intermediate risk for ACS.
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Registered trials
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