ArticleJournal of neurophysiology2010
Temporal patterns of inputs to cerebellum necessary and sufficient for trace eyelid conditioning.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Stimulus Contingency and Task Context Encoding within the Anterior Cingulate-Amygdala-Cerebellum Associative Learning Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- Hippocampal Interneurons are Required for Trace Eyeblink Conditioning in Mice.Neuroscience bulletin · 2021Article
- Intracerebellar cannabinoid administration impairs delay but not trace eyeblink conditioning.Behavioural brain research · 2020Article
- Sensorimotor Coding of Vermal Granule Neurons in the Developing Mammalian Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Response Dynamics in an Olivocerebellar Spiking Neural Network With Non-linear Neuron Properties.Frontiers in computational neuroscience · 2019Article
- Medial Auditory Thalamus Is Necessary for Expression of Auditory Trace Eyelid Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- How the cerebellum learns to build a sequence.eLife · 2018Article
- Cerebellar Processing Common to Delay and Trace Eyelid Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- A cerebellar mechanism for learning prior distributions of time intervals.Nature communications · 2018Article
- Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice.Nature communications · 2017Article
- Cerebellar Roles in Self-Timing for Sub- and Supra-Second Intervals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neural mechanisms of human temporal fear conditioning.Neurobiology of learning and memory · 2016Article
- Contribution of Cerebellar Loops to Action Timing.Current opinion in behavioral sciences · 2016Article
- Links Between Single-Trial Changes and Learning Rate in Eyelid Conditioning.Cerebellum (London, England) · 2016Article
- The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions.Behavioral neuroscience · 2015Review
- Optogenetic stimulation of mPFC pyramidal neurons as a conditioned stimulus supports associative learning in rats.Scientific reports · 2015Article
- Modification of persistent responses in medial prefrontal cortex during learning in trace eyeblink conditioning.Journal of neurophysiology · 2014Article
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3 authors.
Funding
Abstract
Trace eyelid conditioning is a form of associative learning that requires several forebrain structures and cerebellum. Previous work suggests that at least two conditioned stimulus (CS)-driven signals are available to the cerebellum via mossy fiber inputs during trace conditioning: one driven by and terminating with the tone and a second driven by medial prefrontal cortex (mPFC) that persists through the stimulus-free trace interval to overlap in time with the unconditioned stimulus (US). We used electric stimulation of mossy fibers to determine whether this pattern of dual inputs is necessary and sufficient for cerebellar learning to express normal trace eyelid responses. We find that presenting the cerebellum with one input that mimics persistent activity observed in mPFC and the lateral pontine nuclei during trace eyelid conditioning and another that mimics tone-elicited mossy fiber activity is sufficient to produce responses whose properties quantitatively match trace eyelid responses using a tone. Probe trials with each input delivered separately provide evidence that the cerebellum learns to respond to the mPFC-like input (that overlaps with the US) and learns to suppress responding to the tone-like input (that does not). This contributes to precisely timed responses and the well-documented influence of tone offset on the timing of trace responses. Computer simulations suggest that the underlying cerebellar mechanisms involve activation of different subsets of granule cells during the tone and during the stimulus-free trace interval. These results indicate that tone-driven and mPFC-like inputs are necessary and sufficient for the cerebellum to learn well-timed trace conditioned responses.
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