ArticleThe Journal of clinical endocrinology and metabolism2010
Fasting plasma leptin level is a surrogate measure of insulin sensitivity.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Resistant starch lowers postprandial glucose and leptin in overweight adults consuming a moderate-to-high-fat diet: a randomized-controlled trial.Nutrition journal · 2017Trial
- Occupational Stress and Altered Serum Leptin Among Female Workers in Southern Brazil.Diseases (Basel, Switzerland) · 2026Article
- Obesity and type 2 diabetes as chronic inflammation: how does the cytokine evidence align?Frontiers in endocrinology · 2026Review
- Surrogate indices of insulin resistance using the Matsuda index as reference in adult men-a computational approach.Frontiers in endocrinology · 2024Article
- Baseline leptin predicts response to metformin in adolescents with type 1 diabetes and increased body mass index.Diabetes, obesity & metabolism · 2023Article
- Ideal Cardiovascular Health and Adipokine Levels: The Multi-Ethnic Study of Atherosclerosis.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2023Article
- Plasma FGF-21 and Sclerostin Levels, Glycemia, Adiposity, and Insulin Sensitivity in Normoglycemic Black and White Adults.Journal of the Endocrine Society · 2022Article
- The obesity paradox and diabetes.Eating and weight disorders : EWD · 2021Review
- Extreme insulin resistance during pregnancy: a therapeutic challenge.Endocrinology, diabetes & metabolism case reports · 2021Article
- Sex differences in circulating leptin as a marker of adiposity in obese or overweight adolescents with type 1 diabetes.BMJ open diabetes research & care · 2020Article
- Plasma leptin level mirrors metabolome alterations in young adults.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Protective role of lycopene against metabolic disorders induced by chronic bisphenol A exposure in rats.Environmental science and pollution research international · 2020Article
- Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy.Journal of diabetes research · 2017Review
- Article
- Adipokines and Insulin Resistance in Young Adult Survivors of Childhood Cancer.International journal of endocrinology · 2016Article
- Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns.Archives of medical science : AMS · 2015Article
- Steroid replacement in primary adrenal failure does not appear to affect circulating adipokines.Endocrine · 2015Article
- Counterregulation of insulin by leptin as key component of autonomic regulation of body weight.World journal of diabetes · 2014Review
- Modification of high saturated fat diet with n-3 polyunsaturated fat improves glucose intolerance and vascular dysfunction.Diabetes, obesity & metabolism · 2013Article
- Adipokines, body fatness, and insulin resistance among survivors of childhood leukemia.Pediatric blood & cancer · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
contextPublished studies indicate marked variability in plasma leptin levels among persons with similar body mass index (BMI). We tested the hypothesis that such variations in leptin levels reflect differences in insulin sensitivity. SUBJECTS AND
methodsUsing euglycemic clamp, we assessed insulin sensitivity (ISI) in 57 nondiabetic adults (36 women, 21 men), whose BMI ranged from 20 to 78 kg/m2. We identified 38 age-matched subjects, stratified by fasting leptin (normal, <15 ng/ml vs. high, >or=15 ng/ml) and BMI (nonobese, <27 kg/m2 vs. overweight/obese, BMI>or=27 kg/m2) and compared ISI across the four strata.
resultsFasting leptin levels correlated with ISI (r=-0.66 in men and -0.60 in women). In a multivariate regression model, leptin emerged as a strong predictor of ISI (r=-0.41, P=0.0002) after controlling for adiposity, whereas insulin weakened as a predictor (r=-0.32, P=0.0116). From regression plots of ISI vs. BMI and leptin, a BMI greater than 27 kg/m2 and a leptin level greater than 15 ng/dl strongly predicted decreased ISI. A fasting leptin cutoff of 15 ng/ml for detection of insulin sensitivity has a sensitivity of 72.7%, specificity of 56.3%, and positive predictive value of 69.6%. Overweight/obese subjects with fasting leptin less than 15 ng/ml were 100% more insulin sensitive than control subjects with leptin greater than 15 ng/ml.
conclusionsInsulin sensitivity explains about 40% of the variance in fasting leptin levels. Thus, fasting plasma leptin levels probably serve as an endogenous response to ambient insulin resistance and may provide a surrogate measure of insulin action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.