Trial reportThe American journal of clinical nutrition2010
Maternal gestational zinc supplementation does not influence multiple aspects of child development at 54 mo of age in Peru.
Trial report in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Pooled it
- Zinc supplementation for improving pregnancy and infant outcome.The Cochrane database of systematic reviews · 2021Pooled it
- Effects of Nutritional Interventions during Pregnancy on Infant and Child Cognitive Outcomes: A Systematic Review and Meta-Analysis.Nutrients · 2017Pooled it
- Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis.European journal of clinical nutrition · 2015Pooled it
- Zinc supplementation for improving pregnancy and infant outcome.The Cochrane database of systematic reviews · 2015Pooled it
- Effect of zinc supplementation on pregnancy and infant outcomes: a systematic review.Paediatric and perinatal epidemiology · 2012Pooled it
- Does prenatal micronutrient supplementation improve children's mental development? A systematic review.BMC pregnancy and childbirth · 2011Pooled it
- Effect of maternal zinc supplementation on the cardiometabolic profile of Peruvian children: results from a randomized clinical trial.Journal of developmental origins of health and disease · 2017Trial
- The Long Term Impact of Micronutrient Supplementation during Infancy on Cognition and Executive Function Performance in Pre-School Children.Nutrients · 2015Trial
- Nutrition and Brain Development.Current topics in behavioral neurosciences · 2022Article
- Article
- Effects of vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: A systematic review.Campbell systematic reviews · 2021Article
- Nutritional Support of Neurodevelopment and Cognitive Function in Infants and Young Children-An Update and Novel Insights.Nutrients · 2021Review
- Does antenatal micronutrient supplementation improve children's cognitive function? Evidence from the follow-up of a double-blind randomised controlled trial in Nepal.BMJ global health · 2018Article
- Micronutrient deficiencies in pregnancy worldwide: health effects and prevention.Nature reviews. Endocrinology · 2016Review
- Biomarkers of Nutrition for Development (BOND)-Zinc Review.The Journal of nutrition · 2015Article
- Article
- The role of nutrition in children's neurocognitive development, from pregnancy through childhood.Frontiers in human neuroscience · 2013Article
- Review
- Effect of zinc on efficacy of iron supplementation in improving iron and zinc status in women.Journal of nutrition and metabolism · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundZinc is necessary for central nervous system development, and maternal zinc status has been associated with developmental differences in offspring.
objectiveThe objective was to evaluate differences in cognitive, social, and behavioral function in Peruvian children at 54 mo of age whose mothers participated during pregnancy in a zinc supplementation trial.
designWe attempted to follow up 205 children from a prenatal zinc supplementation trial and present data on 184 (90%) children-86 whose mothers took 25 mg zinc/d in addition to 60 mg iron and 250 microg folic acid and 98 whose mothers took iron and folic acid only. Following a standardized protocol, we assessed children's intelligence, language and number skills, representational ability, interpersonal understanding, and adaptive behavior and behavioral adjustment. We also assessed aspects of the mother (eg, age, education, verbal intelligence, stresses, and social support in parenting) and the home environment [HOME (Home Observation for the Measurement of the Environment) inventory].
resultsNo differences were observed between any of the tests used to characterize cognitive, social, or behavioral development (P > 0.05). Child sex, parity, or treatment compliance did not modify the effects of supplementation on any outcomes.
conclusionThe addition of zinc to prenatal supplements did not influence developmental outcomes in Peruvian children when assessed at 4.5 y of age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.