Evidence map›Paper›PMID 20484334›Full record

Trial reportInternational journal of epidemiology2010

Lactation-associated postpartum weight changes among HIV-infected women in Zambia.

Pamela M Murnane, Stephen M Arpadi, Moses Sinkala, Chipepo Kankasa, Mwiya Mwiya, Prisca Kasonde, Donald M Thea, Grace M Aldrovandi, Louise Kuhn

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00310726 (Short Duration Exclusive Breastfeeding With Abrupt Weaning to Reduce the Risk of Mother-to-Child HIV Transmission), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00310726 nacompletednot on this map

Short Duration Exclusive Breastfeeding With Abrupt Weaning to Reduce the Risk of Mother-to-Child HIV Transmission

TypeinterventionalSponsorBoston Medical CenterRan2001 to 2006Enrolled1,435ConditionsHIV InfectionArmsabrupt weaning at 4 months, Continued exclusive breastfeeding
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Pamela M MurnaneCenter for AIDS Prevention Studies, University of California San Francisco, CA, USA.
Stephen M Arpadi
Moses Sinkala
Chipepo Kankasa
Mwiya Mwiya
Prisca Kasonde
Donald M Thea
Grace M Aldrovandi
Louise Kuhn
Columbia University · USSt. Luke's-Roosevelt Hospital Center · USUniversity of Zambia · ZM

Funding

Short Exclusive Breastfeeding to Reduce Postnatal Transmission of HIVR01HD039611 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI THEA, DONALD M · 2000 to 2006
$8.0M
Pathogenesis of Mother to Child Transmission of HIVR01HD040777 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALDROVANDI, GRACE M · 2002 to 2011
$4.4M
Safer Weaning Practices for HIV-infected womenR01HD057617 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUHN, LOUISE · 2007 to 2011
$2.0M
NICHD NIH HHS R01 HD039611NICHD NIH HHS R01 HD39611NICHD NIH HHS R01 HD 40777NICHD NIH HHS R01 HD 57617
6 · The paper itself

Abstract

backgroundThere are concerns about effects of lactation on postpartum weight changes among HIV-infected women because low weight may increase risks of HIV-related disease progression.

methodsThis analysis of postpartum maternal weight change is based on a trial evaluating the effects of shortened breastfeeding on postpartum mother-to-child transmission of HIV in Lusaka, Zambia, in which 958 HIV-infected women were randomized to breastfeed for a short duration (4 months) or for a duration of their own informed choosing (median 16 months). Among 768 women who met inclusion criteria, we compared across the two groups change in weight (kg) and the percent underweight [body mass index (BMI) <18.5] through 24 months. We also examined the effect of breastfeeding in two high-risk groups: those with low BMI and those with low CD4 counts.

resultsOverall, women in the long-duration group gained less weight compared with those in the short-duration group from 4-24 months {1.0 kg [95% confidence interval (CI): 0.3-1.7] vs 2.3 kg (95% CI: 1.6-2.9), P = 0.01}. No association was found between longer breastfeeding and being underweight (odds ratio 1.1; 95% CI: 0.8-1.6; P = 0.40). Effects of lactation in underweight women and women with low CD4 counts were similar to the effects in women with higher BMI and higher CD4 counts. Women with low baseline BMI tended to gain more weight from 4 to 24 months than those with higher BMI, regardless of breastfeeding duration (2.1 kg, 95% CI: 1.3-2.9; P < 0.01).

conclusionsIn this study of HIV-infected breastfeeding women in a low-resource setting, the average change in weight from 4 to 24 months postpartum was a net gain rather than loss. Although longer duration breastfeeding was associated with less weight gain, breastfeeding duration was not associated with being underweight (BMI < 18.5). Weight change associated with longer breastfeeding may be metabolically regulated so that women with low BMI and at risk of wasting are protected from excess weight loss.

Indexed as

Breast FeedingHIV InfectionsWeight GainBody Mass IndexDisease ProgressionFemaleHumansRisk FactorsSocioeconomic FactorsThinnessTime FactorsZambia

Identifiers

PMID20484334
PMCPMC2972438
OpenAlexW2098943795

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.