ArticleDiabetes care2010
Beta-cell function declines within the first year postpartum in women with recent glucose intolerance in pregnancy.
Article in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Body composition changes in the postpartum: a systematic review on measurements and predictors.BMC pregnancy and childbirth · 2026Pooled it
- Pooled it
- Cardiovascular risk factors in women with previous gestational diabetes mellitus: A systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2021Pooled it
- Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2020Pooled it
- Sex of the baby and risk of gestational diabetes mellitus in the mother: a systematic review and meta-analysis.Diabetologia · 2015Pooled it
- Empagliflozin for the preservation of beta-cell function in women with recent gestational diabetes: A randomized placebo-controlled trial.Diabetes, obesity & metabolism · 2025Trial
- Association Between Circulating Gremlin 2 and β-Cell Function Among Participants With Prediabetes and Type 2 Diabetes.Journal of diabetes · 2025Trial
- Type 2 diabetes prevention across the life course.Nature medicine · 2026Review
- Antenatal glycemic control in gestational diabetes and its association with postpartum glucose intolerance and weight retention.Clinics (Sao Paulo, Brazil) · 2026Article
- Perinatal Endocrine-Cardiac Axis: A Narrative Review of Long-Term Cardiovascular Risks in Women with Gestational Diabetes, Hypertensive Disorders, and Thyroid Dysfunction.Biomedicines · 2026Review
- Social determinants of health and recommended A1C monitoring among women with postpartum-onset diabetes: results from a retrospective cohort.BMJ open diabetes research & care · 2026Article
- A pharmacokinetic and pharmacodynamic drug-drug interaction study of dorzagliatin and empagliflozin in patients with type 2 diabetes and obesity: an open-label phase I trial.Nature communications · 2026Article
- Circulating 1,5-anhydroglucitol levels combined with pre-pregnancy BMI is a simple predictive marker of future glucose intolerance in women with gestational diabetes.Journal of endocrinological investigation · 2026Article
- Article
- Delayed insulin secretion in the early postpartum period is associated with future abnormal glucose metabolism among women with a history of gestational diabetes mellitus: a prospective cohort study.BMC pregnancy and childbirth · 2026Article
- Early postpartum dysglycemia after gestational diabetes: β-cell dysfunction and risk stratification in a multiethnic cohort.Frontiers in endocrinology · 2026Article
- Insulin deficiency is associated with early postpartum T2DM in Indian women with gestational diabetes.Frontiers in clinical diabetes and healthcare · 2026Article
- c-Jun regulates postpartum β-cell apoptosis and survival downstream of prolactin signaling.Molecular and cellular endocrinology · 2025Article
- Unveiling Gestational Diabetes: An Overview of Pathophysiology and Management.International journal of molecular sciences · 2025Review
- Association between mean platelet volume and the risk of type 2 diabetes mellitus among women with history of gestational diabetes mellitus.BMC endocrine disorders · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveBoth gestational diabetes mellitus (GDM) and mild glucose intolerance in pregnancy identify women at increased risk of future type 2 diabetes. In this context, we queried whether metabolic changes that occur in the 1st year postpartum vary in relation to gestational glucose tolerance status. RESEARCH DESIGN AND
methodsThree-hundred-and-ninety-two women underwent glucose challenge test (GCT) and oral glucose tolerance test (OGTT) in pregnancy followed by repeat OGTT at both 3 months' postpartum and 12 months' postpartum. The antepartum testing defined four gestational glucose tolerance groups: GDM (n = 107); gestational impaired glucose tolerance (GIGT) (n = 75); abnormal GCT with normal glucose tolerance (NGT) on OGTT (abnormal GCT NGT) (n = 137); and normal GCT with NGT on OGTT (normal GCT NGT) (n = 73).
resultsThe prevalence of dysglycemia progressively increased across the groups from normal GCT NGT to abnormal GCT NGT to GIGT to GDM at both 3 months' postpartum (2.7% to 10.2% to 18.7% to 34.6%, P < 0.0001) and 12 months' postpartum (2.7% to 11.7% to 17.3% to 32.7%, P < 0.0001). Between 3 and 12 months' postpartum, the groups did not differ with respect to changes in waist circumference, weight, or insulin sensitivity. Importantly, however, they exhibited markedly different changes in beta-cell function (Insulin Secretion-Sensitivity Index-2 [ISSI-2]) (P = 0.0036), with ISSI-2 declining in both the GDM and GIGT groups. Furthermore, on multiple linear regression analysis, both GDM (t = -3.06, P = 0.0024) and GIGT (t = -2.18, P = 0.03) emerged as independent negative predictors of the change in ISSI-2 between 3 and 12 months' postpartum.
conclusionsWomen with GDM and GIGT exhibit declining beta-cell function in the 1st year postpartum that likely contributes to their future diabetic risk.
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