Trial reportDiabetes care2010
Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.
Trial report in Diabetes care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men.The Journal of clinical endocrinology and metabolism · 2016Trial
- Trial
- Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism?International journal of endocrinology · 2020Review
- The Association between Serum Testosterone and Risk Factors for Atherosclerosis.Current urology · 2019Article
- Klinefelter syndrome: cardiovascular abnormalities and metabolic disorders.Journal of endocrinological investigation · 2017Review
- Low-dose testosterone alleviates vascular damage caused by castration in male rats in puberty via modulation of the PI3K/AKT signaling pathway.Molecular medicine reports · 2016Article
- Benefits and Consequences of Testosterone Replacement Therapy: A Review.European endocrinology · 2013Review
- Onset of effects of testosterone treatment and time span until maximum effects are achieved.European journal of endocrinology · 2011Review
- Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes.Diabetes care · 2011Review
- Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones.The Journal of clinical endocrinology and metabolism · 2011Review
- The role of hypogonadism in Klinefelter syndrome.Asian journal of andrologyReview
- Associations of endogenous testosterone and lipid profiles in middle-aged to older Taiwanese men.International journal of impotence researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition. RESEARCH DESIGN AND
methodsA randomized clinical trial was performed to create contrasting sex steroid levels in healthy young men: by letrozole (aromatase inhibitor) to lower estradiol (E(2)) and increase testosterone (group T, n = 10) versus letrozole plus E(2) patches to lower T and raise E(2) (group E, n = 10). Mixed meals and hyperinsulinemic-euglycemic clamps were performed before and after a 1-week treatment period.
resultsFollowing intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E.
conclusionsIn healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.