ArticleThe Plant cell2010
The RNA binding protein Tudor-SN is essential for stress tolerance and stabilizes levels of stress-responsive mRNAs encoding secreted proteins in Arabidopsis.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 101 citations in OpenAlex.
- Integrating multiomic resources and gene expression studies to identify candidates for engineering climate-resilientFrontiers in plant science · 2026Review
- Viral proteins suppress rice defenses by boosting OsTSN1 RNA decay via phase separation and multimerization.Nature communications · 2025Article
- Integrating proteomic and phosphoproteomic profiles provide new insights into ABA-dependent signal regulation network in maize response to heat stress.BMC plant biology · 2025Article
- Beware of Sealing Film of Petri Dishes!-Alters the Expression of a Large Number of Genes.International journal of molecular sciences · 2025Article
- The Regulatory Roles of RNA-Binding Proteins in Plant Salt Stress Response.Plants (Basel, Switzerland) · 2025Review
- R-Methylation in Plants: A Key Regulator of Plant Development and Response to the Environment.International journal of molecular sciences · 2024Review
- Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance.Nature communications · 2024Article
- Arabidopsis AGO1 N-terminal extension acts as an essential hub for PRMT5 interaction and post-translational modifications.Nucleic acids research · 2024Article
- The unique dual targeting of AGO1 by two types of PRMT enzymes promotes phasiRNA loading in Arabidopsis thaliana.Nucleic acids research · 2024Article
- Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs.Plant physiology · 2023Article
- The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.FASEB bioAdvances · 2023Article
- RNA-Binding Proteins: The Key Modulator in Stress Granule Formation and Abiotic Stress Response.Frontiers in plant science · 2022Review
- Article
- Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis.The EMBO journal · 2021Article
- Plant RNA Binding Proteins as Critical Modulators in Drought, High Salinity, Heat, and Cold Stress Responses: An Updated Overview.International journal of molecular sciences · 2021Review
- Proteome impact on maize silks under the priming state induced by Trichoderma root colonization.Planta · 2021Article
- The Contribution of Transcriptional Coregulators in the Maintenance of β-cell Function and Identity.Endocrinology · 2021Review
- The TSN1 Binding Protein RH31 Is a Component of Stress Granules and Participates in Regulation of Salt-Stress Tolerance inFrontiers in plant science · 2021Article
- Systemic acquired resistance specific proteome of Arabidopsis thaliana.Plant cell reports · 2020Article
- The increasing diversity and complexity of the RNA-binding protein repertoire in plants.Proceedings. Biological sciences · 2020Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tudor-SN (TSN) copurifies with the RNA-induced silencing complex in animal cells where, among other functions, it is thought to act on mRNA stability via the degradation of specific dsRNA templates. In plants, TSN has been identified biochemically as a cytoskeleton-associated RNA binding activity. In eukaryotes, it has recently been identified as a conserved primary target of programmed cell death-associated proteolysis. We have investigated the physiological role of TSN by isolating null mutations for two homologous genes in Arabidopsis thaliana. The double mutant tsn1 tsn2 displays only mild growth phenotypes under nonstress conditions, but germination, growth, and survival are severely affected under high salinity stress. Either TSN1 or TSN2 alone can complement the double mutant, indicating their functional redundancy. TSN accumulates heterogeneously in the cytosol and relocates transiently to a diffuse pattern in response to salt stress. Unexpectedly, stress-regulated mRNAs encoding secreted proteins are significantly enriched among the transcripts that are underrepresented in tsn1 tsn2. Our data also reveal that TSN is important for RNA stability of its targets. These findings show that TSN is essential for stress tolerance in plants and implicate TSN in new, potentially conserved mechanisms acting on mRNAs entering the secretory pathway.
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