ArticleJournal of immunology (Baltimore, Md. : 1950)2010
B cell development in GALT: role of bacterial superantigen-like molecules.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Bioaerosols and Airway Diseases: Mechanisms of Epithelial Dysfunction, Immune Activation, and Strategies for Exposure Mitigation.Archives of internal medicine research · 2025Article
- Safety and Immunogenicity of InactivatedVaccines · 2022Article
- Mechanisms and Applications of Bacterial Sporulation and Germination in the Intestine.International journal of molecular sciences · 2022Review
- A Promising Insight: The Potential Influence and Therapeutic Value of the Gut Microbiota in GI GVHD.Oxidative medicine and cellular longevity · 2022Review
- Oral vaccination of fish against vibriosis using spore-display technology.Frontiers in immunology · 2022Article
- Effect of Fermented Rapeseed Meal on the Gastrointestinal Microbiota and Immune Status of Rabbit (Animals : an open access journal from MDPI · 2021Article
- Indoor Airborne Microbial Concentration and Dry Eye.American journal of ophthalmology · 2021Observational
- Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract.Frontiers in immunology · 2020Review
- Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity.Journal of immunology research · 2019Review
- Airborne bioaerosols and their impact on human health.Journal of environmental sciences (China) · 2018Review
- The Impact of the Gut Microbiota on Humoral Immunity to Pathogens and Vaccination in Early Infancy.PLoS pathogens · 2016Review
- Chemokine-mediated B cell trafficking during early rabbit GALT development.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Development of CD27+ marginal zone B cells requires GALT.European journal of immunology · 2013Article
- Secretory IgA: Designed for Anti-Microbial Defense.Frontiers in immunology · 2013Article
- Evolution of B cell immunity.Annual review of animal biosciences · 2013Review
- In vivo VL-targeted microbial superantigen induced global shifts in the B cell repertoire.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax.Mucosal immunology · 2012Article
- Corruption of human follicular B-lymphocyte trafficking by a B-cell superantigen.Molecular medicine (Cambridge, Mass.) · 2012Article
- Somatically diversified and proliferating transitional B cells: implications for peripheral B cell homeostasis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Isolation of recombinant antibodies directed against surface proteins of Clostridium difficile.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Intestinal bacteria drive the formation of lymphoid tissues, and in rabbit, bacteria also promote development of the preimmune Ab repertoire and positive selection of B cells in GALT. Previous studies indicated that Bacillus subtilis promotes B cell follicle formation in GALT, and we investigated the mechanism by which B. subtilis stimulates B cells. We found that spores of B. subtilis and other Bacillus species, including Bacillus anthracis, bound rabbit IgM through an unconventional, superantigen-like binding site, and in vivo, surface molecules of B. anthracis spores promoted GALT development. Our study provides direct evidence that B cell development in GALT may be driven by superantigen-like molecules, and furthermore, that bacterial spores modulate host immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.