ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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Who cites it
48 citing papers in PubMed, 82 citations in OpenAlex.
- Getting on your last nerve: IFNs and resistance to infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Silencing YTHDF2 Induces Apoptosis of Neuroblastoma Cells In a Cell Line-Dependent Manner via Regulating the Expression of DLK1.Molecular neurobiology · 2025Article
- Bystander neuronal progenitors in forebrain organoids promote protective antiviral responses.Journal of neuroinflammation · 2025Article
- T cells at the interface of neuroimmune communication.The Journal of allergy and clinical immunology · 2024Review
- The RLR intrinsic antiviral system is expressed in neural retina and restricts lentiviral transduction of human Mueller cells.Experimental eye research · 2023Article
- Article
- Differential Effects of Toll-Like Receptor Activation and Differential Mediation by MAP Kinases of Immune Responses in Microglial Cells.Cellular and molecular neurobiology · 2022Article
- Host immune responses in the central nervous system during fungal infections.Immunological reviews · 2022Review
- Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous System.International journal of molecular sciences · 2022Review
- Antiviral response within different cell types of the CNS.Frontiers in immunology · 2022Review
- Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis.The Journal of experimental medicine · 2021Article
- Review
- Adrenergic regulation of immune cell function and inflammation.Seminars in immunopathology · 2020Review
- Immunomodulatory Strategies in Herpes Simplex Virus Encephalitis.Clinical microbiology reviews · 2020Review
- Activation of type I interferon antiviral response in human neural stem cells.Stem cell research & therapy · 2019Article
- EV71 Infection Induces IFNβ Expression in Neural Cells.Viruses · 2019Article
- Neuroinflammation During RNA Viral Infections.Annual review of immunology · 2019Review
- Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer's Disease.BioMed research international · 2019Review
- Syk and Hrs Regulate TLR3-Mediated Antiviral Response in Murine Astrocytes.Oxidative medicine and cellular longevity · 2019Article
- The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion.Brain, behavior, and immunity · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Innate immune pathways are early defense responses important for the immediate control and eventual clearance of many pathogens, where signaling is initiated via pattern recognition receptor (PRR)-mediated events that occur in a ligand- and cell-type specific manner. Within CNS neurons, innate immune pathways are likely crucial to control pathogens that target these essential yet virtually irreplaceable cells. However, relatively little is known about the induction and regulation of neuronal PRR signaling. In this report, we used human neuronal cell lines and primary rat neuronal cultures to examine PRR expression and function. We found that several innate immune receptor ligands, including Sendai virus, the dsRNA mimetic polyinosinic-polycytidylic acid, and LPS all activated differentiation-dependent neuronal innate immune pathways. Functional genetic analyses revealed that IFN regulatory factor 3-mediated pathways that resulted in IFN-beta transcriptional upregulation were activated in cultured human neuronal cells by the PRRs TLR3, MDA5, or RIG-I in a ligand-specific manner. Furthermore, genome-wide transcriptional array and targeted genetic and pharmacologic analyses identified PI3K signaling as crucial for the induction of innate immune pathways in neurons. These results indicate that human neuronal cells possess specific and functional PRR pathways essential for the effective induction of innate immune responses, and suggest that neurons can play an active role in defense against neurotropic pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.