ReviewEnvironmental health perspectives2010
Breaking patterns of environmentally influenced disease for health risk reduction: immune perspectives.
Review in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 100 citations in OpenAlex.
- Guardians under Siege: Exploring Pollution's Effects on Human Immunity.International journal of molecular sciences · 2024Review
- Public Health Risks of PFAS-Related Immunotoxicity Are Real.Current environmental health reports · 2024Review
- Dietary Approaches from Moms, Farms, and Nature to Overcome Chronic Diseases and the Pharmacracy.Nutrients · 2023Article
- Individual blood concentrations of persistent organic pollutants and chemical elements, and COVID-19: A prospective cohort study in Barcelona.Environmental research · 2023Article
- Alterations in Microbial-Associated Fecal Metabolites in Relation to Arsenic Exposure Among Infants.Exposure and health · 2022Article
- Invited Perspective: Key Characteristics as a Starting Point for Improved Hazard Identification of Immunotoxic Agents.Environmental health perspectives · 2022Article
- Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan following Adverse Childhood Experiences.Microorganisms · 2022Review
- Microbiome First Medicine in Health and Safety.Biomedicines · 2021Review
- Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach methodologies.Archives of toxicology · 2021Review
- Tyroxine Hydroxylase-Positive Neuronal Cell Population is Increased by Temporal Dioxin Exposure at Early Stage of Differentiation from Human Embryonic Stem Cells.International journal of molecular sciences · 2019Article
- Air Pollution Stress and the Aging Phenotype: The Telomere Connection.Current environmental health reports · 2016Review
- Role of Immune and Autoimmune Dysfunction in Schizophrenia.Handbook of behavioral neuroscience · 2016Article
- Fetal Hematopoietic Stem Cells Are the Canaries in the Coal Mine That Portend Later Life Immune Deficiency.Endocrinology · 2015Review
- Mercury Exposure and Antinuclear Antibodies among Females of Reproductive Age in the United States: NHANES.Environmental health perspectives · 2015Article
- Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions.Carcinogenesis · 2015Review
- The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- The Microbiome and Sustainable Healthcare.Healthcare (Basel, Switzerland) · 2015Review
- Developmental exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin attenuates later-life Notch1-mediated T cell development and leukemogenesis.Toxicology and applied pharmacology · 2015Article
- CDC Kerala 14: Early child care practices at home among children (2-6 y) with autism--a case control study.Indian journal of pediatrics · 2014Article
- The effects of environmental toxins on allergic inflammation.Allergy, asthma & immunology research · 2014Review
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4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundDiseases rarely, if ever, occur in isolation. Instead, most represent part of a more complex web or "pattern" of conditions that are connected via underlying biological mechanisms and processes, emerge across a lifetime, and have been identified with the aid of large medical databases.
objectiveWe have described how an understanding of patterns of disease may be used to develop new strategies for reducing the prevalence and risk of major immune-based illnesses and diseases influenced by environmental stimuli.
findingsExamples of recently defined patterns of diseases that begin in childhood include not only metabolic syndrome, with its characteristics of inflammatory dysregulation, but also allergic, autoimmune, recurrent infection, and other inflammatory patterns of disease. The recent identification of major immune-based disease patterns beginning in childhood suggests that the immune system may play an even more important role in determining health status and health care needs across a lifetime than was previously understood.
conclusionsFocusing on patterns of disease, as opposed to individual conditions, offers two important venues for environmental health risk reduction. First, prevention of developmental immunotoxicity and pediatric immune dysfunction can be used to act against multiple diseases. Second, pattern-based treatment of entryway diseases can be tailored with the aim of disrupting the entire disease pattern and reducing the risk of later-life illnesses connected to underlying immune dysfunction. Disease-pattern-based evaluation, prevention, and treatment will require a change from the current approach for both immune safety testing and pediatric disease management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.