ArticleBiophysical journal2010
Quantitative analysis of synaptic release at the photoreceptor synapse.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Presynaptic Proteins and Their Roles in Visual Processing by the Retina.Annual review of vision science · 2024Review
- A theory of synaptic transmission.eLife · 2021Article
- Article
- Transmission at rod and cone ribbon synapses in the retina.Pflugers Archiv : European journal of physiology · 2021Review
- CaeLife · 2019Article
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Kiss-and-Run Is a Significant Contributor to Synaptic Exocytosis and Endocytosis in Photoreceptors.Frontiers in cellular neuroscience · 2017Article
- Synaptic Ribbon Active Zones in Cone Photoreceptors Operate Independently from One Another.Frontiers in cellular neuroscience · 2017Article
- Mechanisms, pools, and sites of spontaneous vesicle release at synapses of rod and cone photoreceptors.The European journal of neuroscience · 2016Article
- Weak endogenous Ca2+ buffering supports sustained synaptic transmission by distinct mechanisms in rod and cone photoreceptors in salamander retina.Physiological reports · 2015Article
- Endogenous calcium buffering at photoreceptor synaptic terminals in salamander retina.Synapse (New York, N.Y.) · 2014Article
- Glycinergic feedback enhances synaptic gain in the distal retina.The Journal of physiology · 2014Article
- Intracellular calcium stores drive slow non-ribbon vesicle release from rod photoreceptors.Frontiers in cellular neuroscience · 2014Article
- Properties of ribbon and non-ribbon release from rod photoreceptors revealed by visualizing individual synaptic vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Regulation of presynaptic strength by controlling Ca2+ channel mobility: effects of cholesterol depletion on release at the cone ribbon synapse.Journal of neurophysiology · 2012Article
- Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca(2+) channels.Journal of neurophysiology · 2011Article
- The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins.Visual neuroscience · 2011Review
- An improved model for the rate-level functions of auditory-nerve fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Calcium cooperativity of exocytosis as a measure of Ca²+ channel domain overlap.Brain research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Exocytosis from the rod photoreceptor is stimulated by submicromolar Ca(2+) and exhibits an unusually shallow dependence on presynaptic Ca(2+). To provide a quantitative description of the photoreceptor Ca(2+) sensor for exocytosis, we tested a family of conventional and allosteric computational models describing the final Ca(2+)-binding steps leading to exocytosis. Simulations were fit to two measures of release, evoked by flash-photolysis of caged Ca(2+): exocytotic capacitance changes from individual rods and postsynaptic currents of second-order neurons. The best simulations supported the occupancy of only two Ca(2+) binding sites on the rod Ca(2+) sensor rather than the typical four or five. For most models, the on-rates for Ca(2+) binding and maximal fusion rate were comparable to those of other neurons. However, the off-rates for Ca(2+) unbinding were unexpectedly slow. In addition to contributing to the high-affinity of the photoreceptor Ca(2+) sensor, slow Ca(2+) unbinding may support the fusion of vesicles located at a distance from Ca(2+) channels. In addition, partial sensor occupancy due to slow unbinding may contribute to the linearization of the first synapse in vision.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.