Evidence map›Paper›PMID 20483193›Full record

ArticleVaccine2010

Population-based analysis of Actinobacillus pleuropneumoniae ApxIVA for use as a DIVA antigen.

Ciaragh O'Neilla, Sophie C P Jones, Janine T Bossé, Conrad M Watson, Susanna M Williamson, Andrew N Rycroft, J Simon Kroll, Helen M Hartley, Paul R Langford

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Rapid Detection ofFrontiers in veterinary science · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ciaragh O'Neilla *Molecular Infectious Diseases Group, Department of Paediatrics, Imperial College London, St Mary's Campus, London, W2 1PG, UK.
Sophie C P Jones *Molecular Infectious Diseases Group, Department of Paediatrics, Imperial College London, St Mary's Campus, London, W2 1PG, UK.
Janine T BosséMolecular Infectious Diseases Group, Department of Paediatrics, Imperial College London, St Mary's Campus, London, W2 1PG, UK.
Conrad M WatsonAFBI-VSD, Stoney Road, Stormont, Belfast, BT4 3SD, UK.
Susanna M WilliamsonVeterinary Laboratories Agency (VLA) Bury St Edmunds, Rougham Hill, Bury St Edmunds, Suffolk, IP33 2RX, UK.
Andrew N RycroftDepartment of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mimms, Herts AL9 7TA, UK.
J Simon KrollMolecular Infectious Diseases Group, Department of Paediatrics, Imperial College London, St Mary's Campus, London, W2 1PG, UK.
Helen M HartleyAFBI-VSD, Stoney Road, Stormont, Belfast, BT4 3SD, UK.
Paul R LangfordMolecular Infectious Diseases Group, Department of Paediatrics, Imperial College London, St Mary's Campus, London, W2 1PG, UK.
Imperial College London · GBGovernment of Northern Ireland · GBRoyal Veterinary College · GBSt Mary's Hospital · GB

Funding

Biotechnology and Biological Sciences Research Council BB/D522062/1Wellcome Trust
6 · The paper itself

Abstract

APXIVA is an RTX toxin of Actinobacillus pleuropneumoniae that is a candidate antigen to differentiate infected from vaccinated animals (DIVA). Insertion of ISApl1 into the apxIVA gene is known to compromise an APXIVA-based DIVA approach, as is potentially a TGG to TGA mutation in the apxIVA gene. ISApl1 was found in 63/349 (18.1%) A. pleuropneumoniae isolates from England and Wales including serovars 2, 3, 6-8 and 12. No ISApl1 insertions into apxIVA were found. Only two serovar 3 isolates contained the TGG to TGA mutation. We conclude that an ApxIVA-based DIVA approach would potentially be viable in England and Wales.

Indexed as

Actinobacillus InfectionsActinobacillus pleuropneumoniaeAnimalsAntigens, BacterialBacterial ProteinsDNA, BacterialEnglandMutagenesis, InsertionalMutationPolymerase Chain ReactionSequence Analysis, DNAWalesAntigens, BacterialApxIVA protein, Actinobacillus pleuropneumoniaeBacterial ProteinsDNA, Bacterial

Identifiers

PMID20483193
PMCPMC4843962
OpenAlexW2002209405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.